Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 303760..304237 Replicon chromosome
Accession NZ_CP007454
Organism Staphylococcus aureus strain 502A isolate RN6607

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CH52_RS01670 Protein ID WP_000052076.1
Coordinates 304049..304237 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CH52_RS01665 Protein ID WP_001059690.1
Coordinates 303760..304020 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CH52_RS01630 299153..299869 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
CH52_RS01635 300017..300439 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
CH52_RS01640 300838..301332 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
CH52_RS01645 301487..302104 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
CH52_RS01650 302177..302758 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
CH52_RS01655 302983..303219 + 237 WP_000349581.1 hypothetical protein -
CH52_RS01660 303216..303419 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CH52_RS01665 303760..304020 + 261 WP_001059690.1 hypothetical protein Antitoxin
CH52_RS01670 304049..304237 + 189 WP_000052076.1 hypothetical protein Toxin
CH52_RS01675 304425..304994 + 570 WP_001106654.1 hypothetical protein -
CH52_RS01680 305082..305366 + 285 WP_001004399.1 hypothetical protein -
CH52_RS01685 305428..305646 + 219 WP_000005886.1 hypothetical protein -
CH52_RS01690 306139..306339 - 201 WP_001059082.1 cold-shock protein -
CH52_RS01695 306696..307382 - 687 WP_000141557.1 thermonuclease family protein -
CH52_RS01700 307723..308244 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T46466 WP_000052076.1 NZ_CP007454:304049-304237 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T46466 NZ_CP007454:304049-304237 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT46466 WP_001059690.1 NZ_CP007454:303760-304020 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT46466 NZ_CP007454:303760-304020 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References