Detailed information of TA system TA046462

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2806670..2807183
• Replicon: chromosome
• Accession: NZ_CP007448
• Organism: Yersinia enterocolitica LC20

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LC20_RS13640
• Protein ID: WP_025378492.1
• Coordinates: 2806899..2807183 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A386HFF3
• Locus tag: LC20_RS13635
• Protein ID: WP_012105237.1
• Coordinates: 2806670..2806909 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LC20_RS13620	2802705..2803454	-	750	WP_050883109.1	phage head morphogenesis protein	-
LC20_RS13625	2803513..2804898	-	1386	WP_100273938.1	DUF1073 domain-containing protein	-
LC20_RS13630	2804901..2806544	-	1644	WP_050941910.1	phage terminase large subunit	-
LC20_RS13635	2806670..2806909	+	240	WP_012105237.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LC20_RS13640	2806899..2807183	+	285	WP_025378492.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LC20_RS13645	2807194..2808201	-	1008	WP_025378624.1	terminase small subunit	-
LC20_RS13650	2808281..2808721	+	441	WP_025378625.1	hypothetical protein	-
LC20_RS13655	2808923..2809177	-	255	WP_025378495.1	hypothetical protein	-
LC20_RS13660	2809180..2809794	-	615	WP_025378626.1	hypothetical protein	-
LC20_RS13665	2809791..2810300	-	510	WP_025378627.1	ParB/Srx family N-terminal domain-containing protein	-
LC20_RS13670	2810536..2810772	-	237	WP_025378628.1	hypothetical protein	-
LC20_RS13675	2810800..2811321	-	522	WP_100273939.1	DUF2514 family protein	-
LC20_RS13680	2811410..2811910	-	501	WP_100274024.1	lysozyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2783238..2844711	61473

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-76)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11217.02 Da
• Isoelectric Point: 10.3007

>T46462 WP_025378492.1 NZ_CP007448:2806899-2807183 [Yersinia enterocolitica LC20]
MTYNLDFDRRALKEWHKLGDTVRQQFKKKLLEVIKNPRVEANKLRDLPDCYKIKLRSAGYRLIYQVQDEKITVFVVAVGK
RDREETYSEAGKRV

Nucleotide

• Length: 285 bp

>T46462 NZ_CP007448:2806899-2807183 [Yersinia enterocolitica LC20]
ATGACTTATAATCTTGATTTTGATCGCCGGGCGCTGAAGGAATGGCATAAGCTCGGCGATACCGTACGTCAGCAATTTAA
GAAAAAGCTGCTCGAAGTGATTAAAAATCCACGCGTTGAAGCCAATAAACTGCGCGACTTACCTGATTGTTACAAAATAA
AACTACGCAGCGCCGGATACCGCCTGATTTATCAGGTGCAAGACGAAAAAATCACGGTTTTTGTGGTTGCCGTGGGTAAA
CGGGATCGTGAAGAAACCTACAGTGAAGCTGGCAAGCGCGTCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8836.12 Da
• Isoelectric Point: 4.5105

>AT46462 WP_012105237.1 NZ_CP007448:2806670-2806909 [Yersinia enterocolitica LC20]
MGNINIRIDDDLKDRSYAVLEKLGVTPSDLLRQTLEYVAQSGKLPFKSVLLTDEDQALVAVVRERLANPQPVRVSLDDL

Nucleotide

• Length: 240 bp

>AT46462 NZ_CP007448:2806670-2806909 [Yersinia enterocolitica LC20]
ATGGGTAACATTAATATTCGCATTGATGATGACTTAAAAGATCGTTCTTATGCGGTACTGGAAAAACTGGGGGTCACTCC
CTCTGATTTGCTGCGCCAGACACTGGAATATGTGGCACAAAGTGGCAAACTGCCCTTTAAATCCGTGTTGCTGACCGATG
AAGATCAAGCACTGGTCGCCGTAGTCAGAGAACGTTTAGCCAATCCACAACCGGTCAGGGTGTCACTGGATGACTTATAA