Detailed information of TA system TA046453

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2664177..2664690
• Replicon: chromosome
• Accession: NZ_CP007448
• Organism: Yersinia enterocolitica LC20

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LC20_RS12845
• Protein ID: WP_025378492.1
• Coordinates: 2664406..2664690 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A386HFF3
• Locus tag: LC20_RS12840
• Protein ID: WP_012105237.1
• Coordinates: 2664177..2664416 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LC20_RS12825	2660212..2660961	-	750	WP_025378489.1	phage head morphogenesis protein	-
LC20_RS12830	2661020..2662405	-	1386	WP_025378490.1	DUF1073 domain-containing protein	-
LC20_RS12835	2662408..2664051	-	1644	WP_025378491.1	phage terminase large subunit	-
LC20_RS12840	2664177..2664416	+	240	WP_012105237.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LC20_RS12845	2664406..2664690	+	285	WP_025378492.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LC20_RS12850	2664701..2665717	-	1017	WP_025378493.1	terminase small subunit	-
LC20_RS12855	2665797..2666237	+	441	WP_025378494.1	hypothetical protein	-
LC20_RS12860	2666439..2666693	-	255	WP_042546137.1	hypothetical protein	-
LC20_RS12865	2666696..2667310	-	615	WP_025378496.1	hypothetical protein	-
LC20_RS12870	2667307..2667816	-	510	WP_025378497.1	ParB/Srx family N-terminal domain-containing protein	-
LC20_RS12875	2668158..2668733	+	576	WP_025378498.1	hypothetical protein	-
LC20_RS23775	2668765..2668935	-	171	WP_193588404.1	hypothetical protein	-
LC20_RS12880	2668970..2669296	-	327	WP_025378499.1	DUF2570 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2638605..2694299	55694

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-76)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11217.02 Da
• Isoelectric Point: 10.3007

>T46453 WP_025378492.1 NZ_CP007448:2664406-2664690 [Yersinia enterocolitica LC20]
MTYNLDFDRRALKEWHKLGDTVRQQFKKKLLEVIKNPRVEANKLRDLPDCYKIKLRSAGYRLIYQVQDEKITVFVVAVGK
RDREETYSEAGKRV

Nucleotide

• Length: 285 bp

>T46453 NZ_CP007448:2664406-2664690 [Yersinia enterocolitica LC20]
ATGACTTATAATCTTGATTTTGATCGCCGGGCGCTGAAGGAATGGCATAAGCTCGGCGATACCGTACGTCAGCAATTTAA
GAAAAAGCTGCTCGAAGTGATTAAAAATCCACGCGTTGAAGCCAATAAACTGCGCGACTTACCTGATTGTTACAAAATAA
AACTACGCAGCGCCGGATACCGCCTGATTTATCAGGTGCAAGACGAAAAAATCACGGTTTTTGTGGTTGCCGTGGGTAAA
CGGGATCGTGAAGAAACCTACAGTGAAGCTGGCAAGCGCGTCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8836.12 Da
• Isoelectric Point: 4.5105

>AT46453 WP_012105237.1 NZ_CP007448:2664177-2664416 [Yersinia enterocolitica LC20]
MGNINIRIDDDLKDRSYAVLEKLGVTPSDLLRQTLEYVAQSGKLPFKSVLLTDEDQALVAVVRERLANPQPVRVSLDDL

Nucleotide

• Length: 240 bp

>AT46453 NZ_CP007448:2664177-2664416 [Yersinia enterocolitica LC20]
ATGGGTAACATTAATATTCGCATTGATGATGACTTAAAAGATCGTTCTTATGCGGTACTGGAAAAACTGGGGGTCACTCC
CTCTGATTTGCTGCGCCAGACACTGGAATATGTGGCACAAAGTGGCAAACTGCCCTTTAAATCCGTGTTGCTGACCGATG
AAGATCAAGCACTGGTCGCCGTAGTCAGAGAACGTTTAGCCAATCCACAACCGGTCAGGGTGTCACTGGATGACTTATAA