Detailed information of TA system TA046452

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 2472689..2473681
• Replicon: chromosome
• Accession: NZ_CP007448
• Organism: Yersinia enterocolitica LC20

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LC20_RS11865
• Protein ID: WP_025378341.1
• Coordinates: 2473223..2473681 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LC20_RS11860
• Protein ID: WP_025378340.1
• Coordinates: 2472689..2473135 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LC20_RS11840	2468361..2469068	+	708	WP_025378336.1	murein tripeptide amidase MpaA	-
LC20_RS11845	2469065..2470036	-	972	WP_025378337.1	L-Ala-D/L-Glu epimerase	-
LC20_RS11850	2470190..2470693	+	504	WP_025378338.1	thiol peroxidase	-
LC20_RS11855	2470791..2472368	-	1578	WP_025378339.1	transcriptional regulator TyrR	-
LC20_RS11860	2472689..2473135	+	447	WP_025378340.1	DUF2384 domain-containing protein	Antitoxin
LC20_RS11865	2473223..2473681	+	459	WP_025378341.1	RES family NAD+ phosphorylase	Toxin
LC20_RS11870	2473685..2474749	-	1065	WP_087768222.1	YcjF family protein	-
LC20_RS11875	2474746..2476143	-	1398	WP_025378342.1	YcjX family protein	-
LC20_RS11880	2476124..2476363	-	240	WP_025378343.1	phage shock protein PspD	-
LC20_RS11885	2476404..2476778	-	375	WP_025378344.1	envelope stress response membrane protein PspC	-
LC20_RS11890	2476778..2477005	-	228	WP_005161022.1	envelope stress response membrane protein PspB	-
LC20_RS11895	2477115..2477780	-	666	WP_025378345.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-146)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (36-90)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17298.69 Da
• Isoelectric Point: 4.9038

>T46452 WP_025378341.1 NZ_CP007448:2473223-2473681 [Yersinia enterocolitica LC20]
MMLYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLVHIQDSSTLSEFELFQIEIEDSNIMLLQPQ
DWPTDWRNDPAPATTMDIGTEWLESESSLGLLVPSTLVPSENNLLLNPRHKDFQTSLHSVKPLSFAFDARLK

Nucleotide

• Length: 459 bp

>T46452 NZ_CP007448:2473223-2473681 [Yersinia enterocolitica LC20]
ATGATGCTCTATCGCATCGTGATGCGCCGCTATCTTGCATCAACCTGGACTGGTTATGGCGCTGAAATCTATGGCGGCCG
GTGGAATCATAAGGGGCATGCTGCCATTTATTTAGCCAGCAGTATATCGTTGGCGATGTTAGAGACATTGGTACATATTC
AGGACAGCTCCACGCTGAGTGAATTCGAGTTATTCCAGATTGAAATTGAAGATAGCAATATTATGCTGCTTCAGCCGCAG
GATTGGCCGACGGACTGGCGCAATGACCCGGCACCTGCGACGACAATGGATATCGGCACCGAATGGCTGGAATCAGAATC
ATCACTTGGATTGCTGGTTCCATCCACTCTGGTGCCATCAGAAAATAATCTACTACTCAACCCGCGACATAAAGATTTCC
AAACTAGCTTACACAGTGTCAAACCACTCTCTTTTGCCTTTGACGCGCGGCTGAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16292.74 Da
• Isoelectric Point: 9.8753

>AT46452 WP_025378340.1 NZ_CP007448:2472689-2473135 [Yersinia enterocolitica LC20]
MRTYHPTPASKTGALWREIGLPASRGTVLVDSIKMGFSVDVIDGIHLWASIPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRRPDSLLETETGALEVCDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT46452 NZ_CP007448:2472689-2473135 [Yersinia enterocolitica LC20]
ATGAGAACATATCACCCCACCCCAGCCAGTAAAACAGGGGCGCTATGGCGAGAAATCGGTTTGCCAGCCAGCCGCGGTAC
GGTATTAGTCGATAGCATCAAAATGGGCTTTTCTGTTGATGTCATTGACGGTATCCATCTATGGGCATCTATCCCTAAAG
CTGAAATCTTACGGGCGACCGGTATTCCCAGCCGCAGTTTGACACGTCGGCGCACCCATGACGGCCGTTTCACCCCTGAA
GAAAGTGAGCGAATTGCGCGTTTCGTCCGGGTAATGGATGCGGCAGTTGATCTGTTTGGCGGTGATAAAGGCAAGGCGAT
TACTTGGATGTCGACCCCGATTAAAGGCCTTGGTCACCGCAGGCCGGACTCCTTGCTGGAGACTGAAACCGGTGCATTAG
AAGTCTGCGATTTAATTGGGCGCTTGGAGCACGGTGTATTTTCATAA