Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2364970..2365532 Replicon chromosome
Accession NZ_CP007448
Organism Yersinia enterocolitica LC20

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag LC20_RS11420 Protein ID WP_025378262.1
Coordinates 2364970..2365326 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag LC20_RS11425 Protein ID WP_025378263.1
Coordinates 2365323..2365532 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LC20_RS11385 2360223..2360465 + 243 WP_025378255.1 hypothetical protein -
LC20_RS11390 2360541..2360786 - 246 WP_025378256.1 DUF1161 domain-containing protein -
LC20_RS11395 2360877..2361248 - 372 WP_025378257.1 DUF1283 family protein -
LC20_RS11400 2361437..2361763 + 327 WP_087769532.1 YnfA family protein -
LC20_RS11405 2361812..2362561 - 750 WP_025378259.1 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG -
LC20_RS11410 2362654..2364066 - 1413 WP_025378260.1 MFS transporter -
LC20_RS11415 2364259..2364606 - 348 WP_025378261.1 hypothetical protein -
LC20_RS11420 2364970..2365326 - 357 WP_025378262.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LC20_RS11425 2365323..2365532 - 210 WP_025378263.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LC20_RS11430 2365824..2367071 - 1248 WP_025378264.1 MFS transporter -
LC20_RS11435 2367401..2368570 + 1170 WP_087769629.1 DNA repair protein -
LC20_RS11440 2368663..2369514 + 852 WP_025378265.1 glutathione-dependent disulfide-bond oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(34-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13157.92 Da        Isoelectric Point: 4.8733

>T46451 WP_025378262.1 NZ_CP007448:c2365326-2364970 [Yersinia enterocolitica LC20]
MIFLTAHDIAEFNAEIIPNGRSDDSKIEAIANRVLNAHHYDNINDVYRLAAIYLIAIGRGHIFLDGNKRTAFQSMVLFLG
INGVDLRASHQLEELTVDAAQGKIGIEQIAEQLRELTE

Download         Length: 357 bp

>T46451 NZ_CP007448:c2365326-2364970 [Yersinia enterocolitica LC20]
ATGATATTTTTAACGGCGCATGATATTGCGGAGTTTAACGCCGAAATTATCCCTAACGGCAGGTCAGATGATAGCAAGAT
TGAAGCTATCGCCAATCGTGTTTTAAATGCGCATCATTATGACAACATCAATGATGTGTACCGGTTGGCGGCTATCTATT
TAATTGCCATCGGCCGAGGTCACATTTTTCTTGATGGGAACAAGCGGACAGCATTTCAAAGCATGGTGTTATTTCTTGGT
ATAAATGGCGTAGACCTACGGGCGAGTCATCAACTGGAAGAATTAACCGTCGATGCGGCACAAGGGAAAATCGGCATCGA
GCAGATAGCGGAACAGTTGCGTGAGCTAACCGAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7747.87 Da        Isoelectric Point: 9.9521

>AT46451 WP_025378263.1 NZ_CP007448:c2365532-2365323 [Yersinia enterocolitica LC20]
MTSISYTAARNNLAKILSEAQNQPVEITRRGQSEVYIISKADYEALMKAKVKAHIQFKHAETINALADR

Download         Length: 210 bp

>AT46451 NZ_CP007448:c2365532-2365323 [Yersinia enterocolitica LC20]
ATGACGAGCATCAGTTATACCGCAGCAAGAAATAATTTAGCCAAGATATTATCAGAAGCGCAAAATCAGCCGGTAGAAAT
CACGCGCCGTGGTCAGAGTGAAGTCTATATTATCAGCAAGGCCGATTATGAAGCGTTGATGAAAGCAAAGGTAAAGGCGC
ACATTCAGTTTAAACATGCTGAAACCATTAATGCGCTTGCGGATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References