Detailed information of TA system TA046450

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 1349204..1349943
• Replicon: chromosome
• Accession: NZ_CP007448
• Organism: Yersinia enterocolitica LC20

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: LC20_RS06475
• Protein ID: WP_087769706.1
• Coordinates: 1349204..1349527 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: LC20_RS06480
• Protein ID: WP_025377492.1
• Coordinates: 1349599..1349943 (+)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LC20_RS06435	1344511..1344750	-	240	Protein_1244	hypothetical protein	-
LC20_RS06440	1345062..1345430	-	369	WP_025377486.1	hypothetical protein	-
LC20_RS06445	1345427..1345651	-	225	WP_087769691.1	hypothetical protein	-
LC20_RS06450	1345788..1346036	-	249	WP_025377487.1	hypothetical protein	-
LC20_RS06455	1346250..1346792	+	543	Protein_1248	ShlB/FhaC/HecB family hemolysin secretion/activation protein	-
LC20_RS06460	1347028..1347759	+	732	WP_087769693.1	hemagglutinin repeat-containing protein	-
LC20_RS06465	1347973..1348329	+	357	WP_025377490.1	hypothetical protein	-
LC20_RS06470	1348337..1348642	+	306	WP_025377491.1	hypothetical protein	-
LC20_RS06475	1349204..1349527	+	324	WP_087769706.1	TA system toxin CbtA family protein	Toxin
LC20_RS06480	1349599..1349943	+	345	WP_025377492.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
LC20_RS06485	1350029..1350883	+	855	WP_025377493.1	DUF4942 domain-containing protein	-
LC20_RS06495	1351731..1352057	-	327	WP_025377494.1	DUF1493 family protein	-
LC20_RS06500	1352182..1352318	-	137	Protein_1256	transposase	-
LC20_RS06505	1352456..1353634	-	1179	WP_140414465.1	hypothetical protein	-
LC20_RS06510	1353930..1354133	+	204	WP_025377496.1	hypothetical protein	-
LC20_RS06515	1354130..1354540	+	411	WP_025377497.1	type 1 fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1345062..1357488	12426

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (10-98)

Antitoxin

• Antitoxin CbeA (14-112)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11868.60 Da
• Isoelectric Point: 6.8791

>T46450 WP_087769706.1 NZ_CP007448:1349204-1349527 [Yersinia enterocolitica LC20]
MKPRATTQGALPVPVIYQQLLTFLLEHHDGLSLNDTPYHDEQVISQQIEHGITVRETVNERVGKFGLVRIDRPGFSLLAQ
DPTLSGGDMLRARSALGLRSPIIDRLA

Nucleotide

• Length: 324 bp

>T46450 NZ_CP007448:1349204-1349527 [Yersinia enterocolitica LC20]
ATGAAACCACGTGCCACAACACAGGGTGCATTGCCCGTGCCTGTTATTTATCAACAGTTGCTCACTTTTCTGCTCGAGCA
CCACGATGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGGTGATTTCACAGCAGATTGAGCATGGCATCACGG
TACGTGAAACCGTCAATGAACGGGTGGGGAAATTTGGCCTAGTCCGCATTGATCGCCCCGGTTTTAGCCTGTTGGCACAA
GACCCGACGCTGAGCGGCGGGGATATGTTACGCGCCCGCAGTGCGCTGGGCCTGCGAAGTCCCATCATTGACCGCCTTGC
CTGA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12642.43 Da
• Isoelectric Point: 6.3176

>AT46450 WP_025377492.1 NZ_CP007448:1349599-1349943 [Yersinia enterocolitica LC20]
MENLEPDTTLPAPIWGLQRDITPRLGARLVQQGNHLHFLSDRAGFIGTFEPDALKTLDTAFPVLIKQLEACLRAGELDPR
RQHCVTVQHAGFSCEADTLGSHGYVYIAVYQKLA

Nucleotide

• Length: 345 bp

>AT46450 NZ_CP007448:1349599-1349943 [Yersinia enterocolitica LC20]
ATGGAAAACCTCGAACCTGATACGACTCTACCGGCTCCCATCTGGGGCTTGCAGCGAGACATCACACCGCGCCTGGGTGC
CAGATTGGTGCAACAGGGCAACCACCTGCATTTTCTATCTGATCGTGCCGGTTTTATCGGCACATTTGAACCTGATGCGC
TGAAAACACTGGATACTGCTTTCCCTGTGCTGATTAAACAGTTGGAAGCCTGTCTGCGCGCCGGTGAACTCGATCCGCGC
CGTCAGCATTGCGTCACCGTGCAGCACGCCGGTTTTAGCTGTGAAGCCGATACACTCGGCAGTCACGGTTATGTCTATAT
CGCGGTGTATCAGAAACTCGCTTGA