Detailed information of TA system TA046421

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 5342173..5342807
• Replicon: chromosome
• Accession: NZ_CP007440
• Organism: Rhodoplanes sp. Z2-YC6860

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A127F0Q7
• Locus tag: RHPLAN_RS25115
• Protein ID: WP_068023637.1
• Coordinates: 5342173..5342574 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: RHPLAN_RS25120
• Protein ID: WP_157100459.1
• Coordinates: 5342571..5342807 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RHPLAN_RS25090	5337448..5337789	-	342	WP_068023632.1	hypothetical protein	-
RHPLAN_RS25095	5338073..5339206	+	1134	WP_068023633.1	sterol desaturase family protein	-
RHPLAN_RS25100	5339426..5340421	-	996	WP_084245501.1	ABC transporter substrate-binding protein	-
RHPLAN_RS25105	5340586..5341380	+	795	WP_068023634.1	ABC transporter ATP-binding protein	-
RHPLAN_RS25110	5341377..5342162	+	786	WP_198164482.1	ABC transporter permease	-
RHPLAN_RS25115	5342173..5342574	-	402	WP_068023637.1	type II toxin-antitoxin system VapC family toxin	Toxin
RHPLAN_RS25120	5342571..5342807	-	237	WP_157100459.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
RHPLAN_RS25125	5342917..5343450	-	534	WP_068031821.1	SRPBCC family protein	-
RHPLAN_RS25130	5343495..5344814	-	1320	WP_068023640.1	TRAP transporter large permease subunit	-
RHPLAN_RS25135	5344820..5345335	-	516	WP_198164483.1	TRAP transporter small permease	-
RHPLAN_RS25140	5345537..5346496	-	960	WP_068023643.1	TRAP transporter substrate-binding protein DctP	-
RHPLAN_RS25145	5346580..5347434	-	855	WP_084245503.1	CPBP family intramembrane metalloprotease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• SpoVT-AbrB domain (10-47)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14365.43 Da
• Isoelectric Point: 4.9662

>T46421 WP_068023637.1 NZ_CP007440:c5342574-5342173 [Rhodoplanes sp. Z2-YC6860]
VTLYLLDTNIFSDLVRNPQGKAAKQIAKRGEDNICTSIIVAAELRYECAKSGSKRLIQAIEELLAEVEVLPFDVPADTEY
GGLRSELEAAGKPIGSNDLLIAAHARAVGATVVTGNVGEFKRVRGLKVENWLD

Nucleotide

• Length: 402 bp

>T46421 NZ_CP007440:c5342574-5342173 [Rhodoplanes sp. Z2-YC6860]
GTGACGCTCTACTTGCTGGATACGAATATTTTTTCGGACCTTGTTAGGAATCCGCAGGGCAAGGCGGCAAAGCAGATCGC
CAAGCGGGGCGAGGACAACATTTGTACCAGCATCATCGTGGCGGCCGAATTGCGTTATGAGTGTGCAAAGAGCGGCTCGA
AACGATTGATCCAAGCGATAGAAGAGCTGCTTGCAGAGGTTGAGGTCCTTCCTTTCGATGTTCCTGCCGACACTGAATAC
GGTGGACTTCGTTCGGAATTGGAAGCCGCTGGAAAGCCGATCGGGAGCAACGACCTTCTGATAGCCGCACACGCACGTGC
CGTCGGCGCCACTGTGGTGACCGGCAATGTCGGTGAATTCAAACGCGTTCGCGGCCTGAAGGTGGAAAATTGGCTCGATT
GA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8878.32 Da
• Isoelectric Point: 6.4713

>AT46421 WP_157100459.1 NZ_CP007440:c5342807-5342571 [Rhodoplanes sp. Z2-YC6860]
VADTRHVRLFRNGRNQAVRIPVEFELPGDEAVMHRDGERLIIEPVRKRGLVALLKAMKPLEESFPEIDDPVPAPEKVL

Nucleotide

• Length: 237 bp

>AT46421 NZ_CP007440:c5342807-5342571 [Rhodoplanes sp. Z2-YC6860]
GTGGCTGATACTAGGCACGTCAGGTTGTTTCGAAATGGCCGCAATCAGGCGGTCCGTATTCCCGTTGAGTTCGAATTGCC
GGGTGATGAAGCCGTCATGCACCGGGACGGTGAACGTCTGATCATCGAGCCCGTGCGCAAACGGGGGCTTGTCGCATTGC
TCAAGGCAATGAAGCCGTTGGAAGAGAGTTTTCCTGAGATTGACGATCCCGTACCTGCGCCGGAGAAGGTGCTGTGA

Structures

Toxin

• AlphaFold DB: A0A127F0Q7