Detailed information of TA system TA046420

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 5184125..5184747
• Replicon: chromosome
• Accession: NZ_CP007440
• Organism: Rhodoplanes sp. Z2-YC6860

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A127EXH1
• Locus tag: RHPLAN_RS24335
• Protein ID: WP_068023225.1
• Coordinates: 5184125..5184517 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: RHPLAN_RS24340
• Protein ID: WP_068023233.1
• Coordinates: 5184514..5184747 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RHPLAN_RS24315	5179126..5179791	+	666	WP_068023205.1	50S ribosomal protein L9	-
RHPLAN_RS24320	5179922..5180704	-	783	WP_068023210.1	hypothetical protein	-
RHPLAN_RS24325	5180985..5182241	+	1257	WP_068023218.1	cyclopropane-fatty-acyl-phospholipid synthase family protein	-
RHPLAN_RS24330	5182562..5184064	+	1503	WP_068023221.1	replicative DNA helicase	-
RHPLAN_RS24335	5184125..5184517	-	393	WP_068023225.1	type II toxin-antitoxin system VapC family toxin	Toxin
RHPLAN_RS24340	5184514..5184747	-	234	WP_068023233.1	hypothetical protein	Antitoxin
RHPLAN_RS39595	5184825..5185793	-	969	WP_157100447.1	hypothetical protein	-
RHPLAN_RS24355	5185969..5187153	+	1185	WP_068023247.1	alanine racemase	-
RHPLAN_RS24360	5187292..5188806	+	1515	WP_068023251.1	autotransporter outer membrane beta-barrel domain-containing protein	-
RHPLAN_RS24365	5188972..5189385	+	414	WP_068023254.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (3-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14249.45 Da
• Isoelectric Point: 6.8803

>T46420 WP_068023225.1 NZ_CP007440:c5184517-5184125 [Rhodoplanes sp. Z2-YC6860]
VIVVDASALLEALLRTPSAKTVEDRLFAPGQTLHAPHLVDVEIAQVVRRFVAKGDIDSKRGAMALTDLANFPLRRYPHDF
LLPRIWDLRNNLTAYDAAYIALAEALDAPLLTRDRGLATAAGHRATIDLV

Nucleotide

• Length: 393 bp

>T46420 NZ_CP007440:c5184517-5184125 [Rhodoplanes sp. Z2-YC6860]
GTGATCGTTGTCGACGCCTCGGCTCTGCTTGAAGCGCTACTTCGCACGCCGTCAGCAAAAACGGTGGAAGATCGGCTGTT
CGCGCCTGGTCAAACGCTTCACGCGCCGCATCTGGTCGATGTCGAAATCGCACAGGTGGTCCGGCGTTTCGTTGCAAAAG
GCGACATCGATAGCAAGCGCGGCGCTATGGCGCTCACTGATTTGGCGAACTTTCCTTTACGGCGATATCCGCACGATTTT
CTTTTGCCGCGCATTTGGGATTTGCGGAACAATCTGACGGCGTATGATGCCGCCTATATCGCGCTGGCTGAGGCACTCGA
CGCCCCGCTGCTGACGCGCGACCGGGGCTTGGCCACAGCGGCGGGTCATCGCGCGACGATCGACTTGGTGTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8599.90 Da
• Isoelectric Point: 11.0798

>AT46420 WP_068023233.1 NZ_CP007440:c5184747-5184514 [Rhodoplanes sp. Z2-YC6860]
MGSVMIQIRNVPDALHRRLKSRAALAGMSLSDYLLSEVRQIAERPTLDELRARLQSRPETALSVTAAEAIRAERDRA

Nucleotide

• Length: 234 bp

>AT46420 NZ_CP007440:c5184747-5184514 [Rhodoplanes sp. Z2-YC6860]
ATGGGAAGCGTGATGATCCAAATCCGCAATGTGCCGGATGCTCTGCATCGCCGGCTCAAATCGCGTGCAGCATTGGCTGG
GATGTCGCTGTCCGACTATCTGCTCAGCGAAGTCCGGCAGATTGCGGAACGACCGACGCTCGATGAACTGCGGGCGCGGT
TGCAGAGCCGCCCCGAAACGGCGCTTTCCGTAACGGCGGCTGAAGCGATCCGCGCGGAGCGCGACCGCGCGTGA

Structures

Toxin

• AlphaFold DB: A0A127EXH1