Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2687773..2688278 Replicon chromosome
Accession NZ_CP007399
Organism Pseudomonas aeruginosa strain F22031

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag F22031_RS12305 Protein ID WP_003121619.1
Coordinates 2687773..2688054 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag F22031_RS12310 Protein ID WP_003112628.1
Coordinates 2688051..2688278 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F22031_RS12285 2683299..2683922 + 624 Protein_2449 GntR family transcriptional regulator -
F22031_RS12290 2683981..2685756 + 1776 WP_049687898.1 group II intron reverse transcriptase/maturase -
F22031_RS31655 2685818..2685943 + 126 Protein_2451 transcriptional regulator -
F22031_RS12295 2686147..2686533 + 387 WP_014602345.1 aegerolysin family protein -
F22031_RS12300 2686565..2687473 - 909 WP_016561475.1 LysR family transcriptional regulator -
F22031_RS12305 2687773..2688054 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
F22031_RS12310 2688051..2688278 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
F22031_RS12315 2688454..2689074 - 621 WP_034063665.1 hypothetical protein -
F22031_RS12320 2689175..2689675 + 501 WP_023107528.1 LEA type 2 family protein -
F22031_RS12325 2689748..2690089 + 342 WP_003101229.1 alkylphosphonate utilization protein -
F22031_RS12330 2690171..2691598 - 1428 WP_003083784.1 GABA permease -
F22031_RS12335 2691767..2693260 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T46408 WP_003121619.1 NZ_CP007399:c2688054-2687773 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T46408 NZ_CP007399:c2688054-2687773 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT46408 WP_003112628.1 NZ_CP007399:c2688278-2688051 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT46408 NZ_CP007399:c2688278-2688051 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References