Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4952732..4953273 Replicon chromosome
Accession NZ_CP007394
Organism Escherichia coli strain ST2747

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CF60_RS24060 Protein ID WP_025263483.1
Coordinates 4952732..4953025 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag CF60_RS24065 Protein ID WP_001139206.1
Coordinates 4953022..4953273 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CF60_RS24045 4948374..4951871 + 3498 WP_025263481.1 autotransporter outer membrane beta-barrel domain-containing protein -
CF60_RS27510 4952046..4952251 - 206 Protein_4533 transposase -
CF60_RS24055 4952241..4952444 + 204 WP_038429594.1 alkaline phosphatase -
CF60_RS24060 4952732..4953025 - 294 WP_025263483.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CF60_RS24065 4953022..4953273 - 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CF60_RS24075 4954220..4955092 - 873 WP_000729436.1 incFII family plasmid replication initiator RepA -
CF60_RS28100 4955253..4955708 + 456 WP_025263484.1 hypothetical protein -
CF60_RS24080 4955956..4956492 + 537 WP_001217006.1 transcription termination factor NusG -
CF60_RS28280 4956525..4956695 - 171 WP_157918115.1 hypothetical protein -
CF60_RS24085 4957040..4957324 + 285 WP_025263485.1 hypothetical protein -
CF60_RS24090 4957907..4958251 + 345 WP_001026850.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11428.46 Da        Isoelectric Point: 10.5077

>T46405 WP_025263483.1 NZ_CP007394:c4953025-4952732 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAQLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERERNNVYHLASERMK

Download         Length: 294 bp

>T46405 NZ_CP007394:c4953025-4952732 [Escherichia coli]
ATGACTTATACAGTAAAATTCCGGGATGATGCACTGAAAGAATGGCTCAGACTGGACAAGACCATTCAGCAGCAGTTCGC
AAAAAAACTGAAAAAATGCAGTGAAAATCCTCATATAGCTTCTGCACAACTACGTGGATTAAAGGACTGCTATAAAATCA
AACTTCGCGCATCAGGTTTTCGTCTGGTTTATCAGGTTATTGATGATATGTTAATTATTGCGGTCGTCGCAGTAGGTAAA
CGTGAACGTGAACGCAACAACGTTTATCATCTCGCCAGTGAACGTATGAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT46405 WP_001139206.1 NZ_CP007394:c4953273-4953022 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp

>AT46405 NZ_CP007394:c4953273-4953022 [Escherichia coli]
ATGCCCAGTATCATTTTGTCTGACACCAGTGCAAGCGTCAGTGAGCTGAAAAAAAATCCGATGGCAACTGTCAGTGCCGG
AGAGGGGTATCCTGTTGCCATTCTTAACCGGAATCAGCCAGCATTCTACTGTGTCCCTGCTGAGCTCTATGAAAGAATGC
TTGATGCCCTGGATGACCAGGAGCTGGTAAAACTGGTTACTGAACGCAGCAGTCAGCCTCTGCATGATGTGGACCTGGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References