Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4646728..4647340 Replicon chromosome
Accession NZ_CP007392
Organism Escherichia coli strain ST2747

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag CF58_RS22580 Protein ID WP_000833473.1
Coordinates 4647155..4647340 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1V3VHB3
Locus tag CF58_RS22575 Protein ID WP_000499746.1
Coordinates 4646728..4647138 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CF58_RS22560 4642240..4643055 - 816 WP_025210977.1 AraC family transcriptional regulator -
CF58_RS22565 4643281..4644681 + 1401 WP_025210978.1 MFS transporter -
CF58_RS22570 4644692..4646656 + 1965 WP_025210979.1 glycoside hydrolase family 127 protein -
CF58_RS22575 4646728..4647138 - 411 WP_000499746.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CF58_RS22580 4647155..4647340 - 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
CF58_RS22590 4647815..4648894 + 1080 WP_000061477.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
CF58_RS22595 4648935..4650473 - 1539 WP_025210980.1 aldehyde dehydrogenase AldB -
CF58_RS22600 4650581..4651876 - 1296 WP_025210981.1 Fic family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T46346 WP_000833473.1 NZ_CP007392:c4647340-4647155 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

>T46346 NZ_CP007392:c4647340-4647155 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15290.22 Da        Isoelectric Point: 4.5486

>AT46346 WP_000499746.1 NZ_CP007392:c4647138-4646728 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDYAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp

>AT46346 NZ_CP007392:c4647138-4646728 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACTACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCAAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTATGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A1V3VHB3

References