Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1351416..1352247 Replicon chromosome
Accession NZ_CP007275
Organism Escherichia coli strain O18

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag NMECO18_RS07090 Protein ID WP_000854814.1
Coordinates 1351873..1352247 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag NMECO18_RS07085 Protein ID WP_001285586.1
Coordinates 1351416..1351784 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMECO18_RS07050 1346473..1347543 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
NMECO18_RS07055 1347679..1348356 + 678 WP_001362823.1 hypothetical protein -
NMECO18_RS07060 1348372..1348782 + 411 WP_000846704.1 hypothetical protein -
NMECO18_RS07065 1349003..1349824 + 822 WP_001234570.1 DUF945 domain-containing protein -
NMECO18_RS07070 1350087..1350560 + 474 WP_000855074.1 antirestriction protein -
NMECO18_RS07075 1350576..1351052 + 477 WP_001351157.1 RadC family protein -
NMECO18_RS07080 1351121..1351342 + 222 WP_000692323.1 DUF987 domain-containing protein -
NMECO18_RS07085 1351416..1351784 + 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
NMECO18_RS07090 1351873..1352247 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
NMECO18_RS07095 1352244..1352438 + 195 WP_000988601.1 hypothetical protein -
NMECO18_RS26845 1352451..1352564 + 114 WP_001161660.1 DUF957 domain-containing protein -
NMECO18_RS25550 1352853..1352999 - 147 Protein_1345 transposase domain-containing protein -
NMECO18_RS07105 1353053..1353235 + 183 WP_001016348.1 hypothetical protein -
NMECO18_RS07110 1353336..1353665 - 330 WP_000450409.1 DUF496 family protein -
NMECO18_RS07115 1353837..1354895 - 1059 WP_001200890.1 FUSC family protein -
NMECO18_RS07120 1355093..1355566 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
NMECO18_RS07125 1355685..1356850 - 1166 Protein_1350 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T46259 WP_000854814.1 NZ_CP007275:1351873-1352247 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T46259 NZ_CP007275:1351873-1352247 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT46259 WP_001285586.1 NZ_CP007275:1351416-1351784 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT46259 NZ_CP007275:1351416-1351784 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References