Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1201624..1202102 Replicon chromosome
Accession NZ_CP007275
Organism Escherichia coli strain O18

Toxin (Protein)


Gene name parE_1 Uniprot ID D8A5B3
Locus tag NMECO18_RS06505 Protein ID WP_000936799.1
Coordinates 1201815..1202102 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID D8A5B4
Locus tag NMECO18_RS06500 Protein ID WP_000100899.1
Coordinates 1201624..1201815 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMECO18_RS25445 1197117..1197395 - 279 WP_024193993.1 hypothetical protein -
NMECO18_RS06465 1197563..1197718 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
NMECO18_RS06470 1197956..1198621 - 666 WP_000150294.1 epoxyqueuosine reductase QueH -
NMECO18_RS06475 1198796..1199221 - 426 WP_001151152.1 DUF977 family protein -
NMECO18_RS06480 1199262..1200332 - 1071 WP_001262357.1 hypothetical protein -
NMECO18_RS06485 1200404..1200829 - 426 WP_000693918.1 Rha family transcriptional regulator -
NMECO18_RS06490 1200813..1201085 - 273 WP_000887447.1 helix-turn-helix domain-containing protein -
NMECO18_RS06495 1201195..1201596 + 402 WP_001329851.1 helix-turn-helix domain-containing protein -
NMECO18_RS06500 1201624..1201815 + 192 WP_000100899.1 hypothetical protein Antitoxin
NMECO18_RS06505 1201815..1202102 + 288 WP_000936799.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NMECO18_RS06510 1202373..1202525 + 153 WP_000379609.1 DUF1391 family protein -
NMECO18_RS06515 1202537..1202911 + 375 WP_001553098.1 hypothetical protein -
NMECO18_RS06520 1202901..1203122 - 222 WP_000202161.1 hypothetical protein -
NMECO18_RS06530 1203690..1204538 + 849 WP_000935606.1 Rha family phage regulatory protein -
NMECO18_RS06535 1204584..1204805 + 222 WP_000560231.1 cell division protein FtsZ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ybtS / ybtX / ybtQ / ybtP 1170476..1217739 47263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10929.85 Da        Isoelectric Point: 10.1360

>T46258 WP_000936799.1 NZ_CP007275:1201815-1202102 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENIPAARRLKIRIETSVLALSEHPYLYPPSDRVSGLREIVVHPNYIVLYRVATSSIE
IANIVHARRQFPFPI

Download         Length: 288 bp

>T46258 NZ_CP007275:1201815-1202102 [Escherichia coli]
ATGTTACCCATTTTGTGGCTACCATCTGCTCGCGATGATTTGCGTCAGATCGTAGCCTATATTGCTAAGGAAAATATTCC
TGCAGCACGCAGACTAAAAATACGGATTGAAACGTCTGTTTTAGCCCTCTCTGAGCATCCATATCTATATCCGCCAAGTG
ATCGAGTATCCGGTTTGCGGGAAATTGTGGTTCACCCTAATTATATCGTTTTGTACCGAGTAGCAACTTCAAGCATTGAA
ATTGCAAATATTGTGCATGCCCGCCGACAATTTCCCTTCCCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7035.80 Da        Isoelectric Point: 4.0270

>AT46258 WP_000100899.1 NZ_CP007275:1201624-1201815 [Escherichia coli]
MSTALSPIVSEFETTEQENSYNEWLRAKVASSLADPRPSIPHDEVMAEMENLIAQIAVTNRSE

Download         Length: 192 bp

>AT46258 NZ_CP007275:1201624-1201815 [Escherichia coli]
ATGAGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTACGCGC
TAAAGTGGCGTCAAGCCTTGCAGACCCTCGTCCCTCAATTCCACATGATGAGGTAATGGCTGAAATGGAGAATCTTATTG
CTCAAATTGCTGTAACTAACAGGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D8A5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A161RC07

References