Detailed information of TA system TA046239

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 207144..207942
• Replicon: chromosome
• Accession: NZ_CP007275
• Organism: Escherichia coli strain O18

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: Q1RDD2
• Locus tag: NMECO18_RS01020
• Protein ID: WP_001094434.1
• Coordinates: 207568..207942 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: NMECO18_RS01015
• Protein ID: WP_001552747.1
• Coordinates: 207144..207521 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NMECO18_RS00985	204022..204843	+	822	WP_001234585.1	DUF945 domain-containing protein	-
NMECO18_RS00990	204843..205088	+	246	WP_001164966.1	hypothetical protein	-
NMECO18_RS00995	205182..205655	+	474	WP_001542276.1	antirestriction protein	-
NMECO18_RS01000	205671..206147	+	477	WP_001186727.1	RadC family protein	-
NMECO18_RS01005	206210..206431	+	222	WP_000692315.1	DUF987 domain-containing protein	-
NMECO18_RS01010	206450..207094	+	645	WP_000086759.1	hypothetical protein	-
NMECO18_RS01015	207144..207521	+	378	WP_001552747.1	type IV toxin-antitoxin system toxin CbtA	Antitoxin
NMECO18_RS01020	207568..207942	+	375	WP_001094434.1	TA system toxin CbtA family protein	Toxin
NMECO18_RS01025	207939..208430	+	492	WP_000976859.1	hypothetical protein	-
NMECO18_RS01030	208442..208639	+	198	WP_000839257.1	DUF957 domain-containing protein	-
NMECO18_RS01035	208732..209574	+	843	WP_001280460.1	DUF4942 domain-containing protein	-
NMECO18_RS01045	210045..210983	+	939	WP_000351298.1	glyoxylate/hydroxypyruvate reductase GhrA	-
NMECO18_RS01050	211038..211775	+	738	WP_000283664.1	zinc-binding phosphatase	-
NMECO18_RS01055	211799..212353	+	555	WP_001001909.1	molecular chaperone YcdY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13921.82 Da
• Isoelectric Point: 6.8517

>T46239 WP_001094434.1 NZ_CP007275:207568-207942 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Nucleotide

• Length: 375 bp

>T46239 NZ_CP007275:207568-207942 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATAACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13757.63 Da
• Isoelectric Point: 6.3127

>AT46239 WP_001552747.1 NZ_CP007275:207144-207521 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRTGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Nucleotide

• Length: 378 bp

>AT46239 NZ_CP007275:207144-207521 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCACCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGAAGCTGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCACCCGCAATCACCGTATAA

Structures

Toxin

• AlphaFold DB: Q1RDD2