Detailed information of TA system TA046210

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): spoIISABC/SpoIISA-SpoIISB
• Location: 1270559..1271476
• Replicon: chromosome
• Accession: NZ_CP007244
• Organism: Bacillus amyloliquefaciens subsp. plantarum TrigoCor1448

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: AJ82_RS06515
• Protein ID: WP_015239694.1
• Coordinates: 1270730..1271476 (-)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: spoIISB
• Uniprot ID: I2HQ14
• Locus tag: AJ82_RS06510
• Protein ID: WP_003154807.1
• Coordinates: 1270559..1270729 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AJ82_RS06475	1265771..1267360	+	1590	WP_015239691.1	hypothetical protein	-
AJ82_RS06480	1267373..1267798	+	426	WP_051483351.1	hypothetical protein	-
AJ82_RS06485	1267803..1268000	+	198	WP_012117366.1	XkdX family protein	-
AJ82_RS06490	1268057..1268818	+	762	WP_025284613.1	hypothetical protein	-
AJ82_RS06495	1268870..1269133	+	264	WP_003154815.1	hemolysin XhlA family protein	-
AJ82_RS06500	1269147..1269410	+	264	WP_003154813.1	phage holin	-
AJ82_RS06505	1269424..1270302	+	879	WP_025284614.1	N-acetylmuramoyl-L-alanine amidase	-
AJ82_RS06510	1270559..1270729	-	171	WP_003154807.1	type II toxin-antitoxin system SpoIISB family antitoxin	Antitoxin
AJ82_RS06515	1270730..1271476	-	747	WP_015239694.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
AJ82_RS06520	1271584..1272582	-	999	WP_007407255.1	inorganic phosphate transporter	-
AJ82_RS06525	1272595..1273212	-	618	WP_003154804.1	DUF47 domain-containing protein	-
AJ82_RS06530	1273498..1274814	-	1317	WP_015239695.1	amino acid permease	-
AJ82_RS06535	1275137..1276087	+	951	WP_012117369.1	ring-cleaving dioxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (3-239)

Antitoxin

• Antitoxin SpoIISB (1-56)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 29135.61 Da
• Isoelectric Point: 4.7003

>T46210 WP_015239694.1 NZ_CP007244:c1271476-1270730 [Bacillus velezensis TrigoCor1448]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAEWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Nucleotide

• Length: 747 bp

>T46210 NZ_CP007244:c1271476-1270730 [Bacillus velezensis TrigoCor1448]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCGCTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGAATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGAGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCAGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6676.74 Da
• Isoelectric Point: 10.9273

>AT46210 WP_003154807.1 NZ_CP007244:c1270729-1270559 [Bacillus velezensis TrigoCor1448]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Nucleotide

• Length: 171 bp

>AT46210 NZ_CP007244:c1270729-1270559 [Bacillus velezensis TrigoCor1448]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Structures

Antitoxin

• AlphaFold DB: I2HQ14