Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1559368..1560041 Replicon chromosome
Accession NZ_CP007243
Organism Leptospirillum ferriphilum YSK

Toxin (Protein)


Gene name vapC Uniprot ID A0A059XUR7
Locus tag Y981_RS07740 Protein ID WP_038505673.1
Coordinates 1559619..1560041 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A059XQG6
Locus tag Y981_RS07735 Protein ID WP_038505670.1
Coordinates 1559368..1559622 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y981_RS07705 1555558..1556307 + 750 WP_148302439.1 Crp/Fnr family transcriptional regulator -
Y981_RS07710 1556696..1557103 + 408 WP_158423156.1 hypothetical protein -
Y981_RS07730 1558086..1558652 + 567 WP_038505667.1 Uma2 family endonuclease -
Y981_RS07735 1559368..1559622 + 255 WP_038505670.1 plasmid stabilization protein Antitoxin
Y981_RS07740 1559619..1560041 + 423 WP_038505673.1 type II toxin-antitoxin system VapC family toxin Toxin
Y981_RS12700 1560064..1560345 - 282 WP_148302467.1 XRE family transcriptional regulator -
Y981_RS12435 1560450..1561053 - 604 Protein_1458 transposase -
Y981_RS12060 1561286..1562050 - 765 WP_051613842.1 HD-GYP domain-containing protein -
Y981_RS07770 1562907..1563554 + 648 WP_051613946.1 TetR/AcrR family transcriptional regulator -
Y981_RS07775 1563564..1563926 + 363 WP_038505682.1 DsrE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15123.34 Da        Isoelectric Point: 5.1748

>T46206 WP_038505673.1 NZ_CP007243:1559619-1560041 [Leptospirillum ferriphilum YSK]
MIVLDTNVVSEAMKPEPQASVQAWLDRQTSETLYLSSVTIAELLFCIRSLPAGRRRKILDATLDGLLALFGERVLPFDTD
AARHFAELAVTARSAGKGFPTPDGYIAAIAASRGFIVATRDVSSFQAAGLKVINPWEAET

Download         Length: 423 bp

>T46206 NZ_CP007243:1559619-1560041 [Leptospirillum ferriphilum YSK]
ATGATCGTTCTGGATACCAACGTCGTCTCCGAGGCGATGAAGCCGGAGCCGCAAGCGTCCGTACAGGCCTGGCTTGACAG
ACAAACATCGGAAACCCTTTACCTGTCGAGCGTCACCATTGCCGAATTGCTGTTCTGCATCCGTTCTCTGCCAGCAGGGC
GGCGCAGGAAGATCCTGGATGCGACGCTGGATGGCTTGCTGGCATTGTTCGGAGAGCGCGTCTTGCCATTTGACACAGAC
GCCGCCCGACACTTCGCCGAGCTGGCTGTGACGGCAAGGTCTGCCGGGAAAGGTTTTCCGACACCGGACGGCTATATCGC
AGCGATTGCGGCTTCCCGGGGCTTCATTGTCGCCACGCGCGATGTCTCTTCATTCCAGGCAGCAGGCCTGAAAGTCATCA
ATCCCTGGGAGGCGGAAACATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9551.98 Da        Isoelectric Point: 6.4764

>AT46206 WP_038505670.1 NZ_CP007243:1559368-1559622 [Leptospirillum ferriphilum YSK]
MATVTVRNLPDEVHRALRVRASMHGRSTEAEIRSILEAAVRPPERLRLGTALTELGRRVGLLEEDFAVFEEVRDKMPAEP
VRFE

Download         Length: 255 bp

>AT46206 NZ_CP007243:1559368-1559622 [Leptospirillum ferriphilum YSK]
ATGGCGACAGTCACCGTTCGAAATCTGCCGGACGAGGTGCACCGTGCTCTTCGGGTGCGAGCGTCGATGCATGGTCGCAG
TACCGAGGCGGAAATCCGTTCCATTCTTGAAGCGGCTGTCCGGCCACCGGAGCGTCTCCGTTTAGGGACAGCCTTGACGG
AGCTGGGTCGTCGCGTTGGACTTTTGGAGGAGGATTTCGCCGTTTTTGAAGAGGTCCGTGACAAGATGCCAGCTGAGCCC
GTGAGATTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A059XUR7

Antitoxin

Source ID Structure
AlphaFold DB A0A059XQG6

References