Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1555363..1555975 Replicon chromosome
Accession NZ_CP007241
Organism Streptococcus pyogenes strain 1E1

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag STAB904_RS07670 Protein ID WP_002982731.1
Coordinates 1555640..1555975 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag STAB904_RS07665 Protein ID WP_002988079.1
Coordinates 1555363..1555650 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STAB904_RS07640 1550544..1551527 - 984 WP_014407847.1 tagatose-bisphosphate aldolase -
STAB904_RS07645 1551531..1552460 - 930 WP_038434267.1 tagatose-6-phosphate kinase -
STAB904_RS07650 1552506..1553021 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
STAB904_RS07655 1553056..1553484 - 429 WP_038434268.1 galactose-6-phosphate isomerase subunit LacA -
STAB904_RS07660 1553929..1554702 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
STAB904_RS07665 1555363..1555650 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
STAB904_RS07670 1555640..1555975 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
STAB904_RS09380 1556127..1556597 + 471 Protein_1448 integrase -
STAB904_RS09120 1556711..1557061 + 351 WP_111679863.1 tyrosine-type recombinase/integrase -
STAB904_RS07675 1557229..1557621 - 393 WP_002982716.1 30S ribosomal protein S9 -
STAB904_RS07680 1557642..1558088 - 447 WP_002982710.1 50S ribosomal protein L13 -
STAB904_RS07685 1558306..1558512 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
STAB904_RS07690 1558509..1559208 - 700 Protein_1453 hypothetical protein -
STAB904_RS07695 1559344..1560204 - 861 WP_002982687.1 DegV family protein -
STAB904_RS07700 1560301..1560819 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T46202 WP_002982731.1 NZ_CP007241:1555640-1555975 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T46202 NZ_CP007241:1555640-1555975 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT46202 WP_002988079.1 NZ_CP007241:1555363-1555650 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT46202 NZ_CP007241:1555363-1555650 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAACAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References