Detailed information of TA system TA046200

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 4257136..4258071
• Replicon: chromosome
• Accession: NZ_CP007230
• Organism: Yersinia similis strain Y_sim_228

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0T9PIB1
• Locus tag: BF17_RS19390
• Protein ID: WP_025383992.1
• Coordinates: 4257613..4258071 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: BF17_RS19385
• Protein ID: WP_002210982.1
• Coordinates: 4257136..4257582 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BF17_RS19365	4252695..4253402	+	708	WP_025383988.1	murein tripeptide amidase MpaA	-
BF17_RS19370	4253426..4254400	-	975	WP_025383989.1	L-Ala-D/L-Glu epimerase	-
BF17_RS19375	4254565..4255068	+	504	WP_025383990.1	thiol peroxidase	-
BF17_RS19380	4255239..4256816	-	1578	WP_025383991.1	transcriptional regulator TyrR	-
BF17_RS19385	4257136..4257582	+	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
BF17_RS19390	4257613..4258071	+	459	WP_025383992.1	RES family NAD+ phosphorylase	Toxin
BF17_RS19395	4258078..4259139	-	1062	WP_025383993.1	YcjF family protein	-
BF17_RS19400	4259136..4260533	-	1398	WP_025383994.1	YcjX family protein	-
BF17_RS19405	4260514..4260756	-	243	WP_025383995.1	phage shock protein PspD	-
BF17_RS19410	4260841..4261200	-	360	WP_025383996.1	envelope stress response membrane protein PspC	-
BF17_RS19415	4261200..4261427	-	228	WP_025383997.1	envelope stress response membrane protein PspB	-
BF17_RS19420	4261589..4262254	-	666	WP_025383998.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16982.43 Da
• Isoelectric Point: 5.1121

>T46200 WP_025383992.1 NZ_CP007230:4257613-4258071 [Yersinia similis]
MMLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVTTMDVGTEWLESGSSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T46200 NZ_CP007230:4257613-4258071 [Yersinia similis]
ATGATGCTATACCGCATTGTTATGCGCCGCTATCTCGCGTCAGCATGGACCGGTTACGGCGCTGAGATCTATGGTGGTCG
TTGGAATCATAAAGGCCACGCTGCCATCTATTTAGCCAGTAGTATTTCATTGGCCATGCTCGAAACACTGGCTCATATTC
AGGACAGTTCAACGCTCAGCGAGTTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GATTGGCCCACGGACTGGCGTAGCGATCCGGCACCGGTGACGACTATGGATGTCGGCACCGAGTGGCTAGAATCAGGATC
CTCGGTAGGGTTACTGGTCCCATCCACCTTGGTGCCGTCAGAAAACAACTTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCTTGTTTAGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGACCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT46200 WP_002210982.1 NZ_CP007230:4257136-4257582 [Yersinia similis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT46200 NZ_CP007230:4257136-4257582 [Yersinia similis]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCTGCTAGCCGCGGCAC
AATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGTATTCATTTGTGGGCATCAATGCCTAAAG
CTGAAATATTACGTGCCACCGGTATCCCCAGCCGTAGCTTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCAGAA
GAAAGCGAGAGAATTGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGAGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTATCGCAGCCCAGATTCCCTACTGGAAACCGAAACTGGCGCACTAG
AAGTGTGTGATTTGATCGGTCGGTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0T9PIB1

Antitoxin

• AlphaFold DB: A0A0E8XFL1