Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3809623..3810218 Replicon chromosome
Accession NZ_CP007230
Organism Yersinia similis strain Y_sim_228

Toxin (Protein)


Gene name doc Uniprot ID A0A0T9RS91
Locus tag BF17_RS17430 Protein ID WP_025383660.1
Coordinates 3809844..3810218 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0T9RQT5
Locus tag BF17_RS17425 Protein ID WP_025383659.1
Coordinates 3809623..3809847 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BF17_RS17390 3805086..3805373 + 288 Protein_3325 type VI secretion system tube protein Hcp -
BF17_RS17395 3805439..3805747 + 309 WP_019083256.1 transposase -
BF17_RS17400 3805693..3806586 + 894 Protein_3327 IS3 family transposase -
BF17_RS24005 3806587..3806811 + 225 WP_144236091.1 type VI secretion system tube protein Hcp -
BF17_RS17405 3806822..3807487 + 666 WP_012413674.1 hypothetical protein -
BF17_RS17415 3807681..3808085 - 405 WP_025383657.1 phage virion morphogenesis protein -
BF17_RS17420 3808531..3809499 + 969 WP_158499220.1 IS630 family transposase -
BF17_RS17425 3809623..3809847 + 225 WP_025383659.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BF17_RS17430 3809844..3810218 + 375 WP_025383660.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
BF17_RS17435 3810281..3811038 + 758 Protein_3334 phage baseplate protein -
BF17_RS17440 3811559..3812254 - 696 Protein_3335 hypothetical protein -
BF17_RS17450 3812586..3812828 - 243 WP_025383662.1 phage virion morphogenesis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3755574..3812828 57254
- flank IS/Tn - - 3808489..3809499 1010


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-54)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13360.20 Da        Isoelectric Point: 4.6194

>T46199 WP_025383660.1 NZ_CP007230:3809844-3810218 [Yersinia similis]
MIFFLSVEQVIAIHDSQLESYGGLAGYRDIGLVEGMVARVENLHAYQGESDLFVLAASLLLSIARGHGFNDANKRTSVAS
AMVFLDMNGAPIIPTEGFADFVVEAAQGIHDVHAVAQELKRLTN

Download         Length: 375 bp

>T46199 NZ_CP007230:3809844-3810218 [Yersinia similis]
ATGATTTTTTTCTTATCTGTTGAGCAGGTCATAGCCATCCACGACAGTCAGTTAGAGTCTTATGGTGGGCTGGCAGGATA
CAGAGATATTGGTCTTGTTGAAGGAATGGTGGCCCGCGTTGAAAACCTTCATGCATACCAAGGTGAAAGTGATTTGTTTG
TGCTGGCCGCGTCGCTGTTGCTTTCAATAGCTCGAGGGCATGGCTTCAATGATGCAAATAAAAGAACTTCTGTTGCATCA
GCAATGGTATTTCTGGATATGAATGGTGCACCCATAATTCCGACAGAGGGTTTCGCTGACTTTGTGGTAGAAGCGGCGCA
GGGAATTCATGATGTGCATGCTGTAGCGCAAGAGCTGAAGAGGCTCACAAATTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8270.58 Da        Isoelectric Point: 10.4836

>AT46199 WP_025383659.1 NZ_CP007230:3809623-3809847 [Yersinia similis]
MITLTFSDARQKFSSVLDTAVNQPVRITRRSAPDMVVITAEQFAELQQAKFDASLARVMGKPKNQALFKELADK

Download         Length: 225 bp

>AT46199 NZ_CP007230:3809623-3809847 [Yersinia similis]
ATGATCACCCTGACCTTTTCCGATGCTCGTCAGAAATTTTCCAGCGTACTAGATACCGCCGTTAATCAGCCCGTGAGGAT
TACCCGCCGTTCAGCTCCTGATATGGTGGTCATCACTGCTGAGCAGTTTGCAGAGTTACAGCAGGCTAAATTTGATGCGT
CTCTTGCTCGGGTGATGGGCAAGCCAAAGAATCAGGCCTTGTTCAAGGAACTTGCAGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9RS91

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9RQT5

References