Detailed information of TA system TA046197

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 2918276..2918976
• Replicon: chromosome
• Accession: NZ_CP007230
• Organism: Yersinia similis strain Y_sim_228

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: BF17_RS13020
• Protein ID: WP_025382932.1
• Coordinates: 2918276..2918647 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: BF17_RS13025
• Protein ID: WP_025382933.1
• Coordinates: 2918644..2918976 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BF17_RS12980	2913500..2914201	+	702	WP_025382924.1	WYL domain-containing protein	-
BF17_RS12985	2914207..2914854	+	648	WP_025382925.1	hypothetical protein	-
BF17_RS12990	2914886..2915338	+	453	WP_025382926.1	hypothetical protein	-
BF17_RS12995	2915377..2915787	+	411	WP_158499227.1	hypothetical protein	-
BF17_RS13000	2915911..2916732	+	822	WP_025382928.1	DUF945 domain-containing protein	-
BF17_RS13005	2916959..2917390	+	432	WP_025382929.1	antirestriction protein	-
BF17_RS13010	2917422..2917895	+	474	WP_025382930.1	DNA repair protein RadC	-
BF17_RS13015	2917889..2918221	+	333	WP_025382931.1	hypothetical protein	-
BF17_RS13020	2918276..2918647	+	372	WP_025382932.1	TA system toxin CbtA family protein	Toxin
BF17_RS13025	2918644..2918976	+	333	WP_025382933.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
BF17_RS13030	2919061..2919915	+	855	WP_025382934.1	DUF4942 domain-containing protein	-
BF17_RS23750	2920048..2920494	-	447	WP_050103421.1	tyrosine-type recombinase/integrase	-
BF17_RS13040	2920874..2921506	+	633	WP_025382936.1	hypothetical protein	-
BF17_RS13045	2921871..2922176	+	306	WP_025382937.1	hypothetical protein	-
BF17_RS13050	2922434..2922756	-	323	Protein_2496	class I SAM-dependent methyltransferase	-
BF17_RS23755	2922818..2923075	-	258	WP_071825484.1	YjhX family toxin	-
BF17_RS13060	2923304..2923748	+	445	Protein_2498	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	yapC	2896713..2937458	40745

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (13-101)

Antitoxin

• Antitoxin CbeA (9-108)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13577.64 Da
• Isoelectric Point: 6.9870

>T46197 WP_025382932.1 NZ_CP007230:2918276-2918647 [Yersinia similis]
MKPHPTTAGALPVPAIYQQLLAFLLEHHYGLSLNDTPYHDEQAIAQQIEQGISVGDTINALVDKYVLVRIGRNGFSALAQ
DPMLSKGDIVRARQAAGLWRAHFPPMLLYPTESLNPIPQRPLT

Nucleotide

• Length: 372 bp

>T46197 NZ_CP007230:2918276-2918647 [Yersinia similis]
ATGAAACCACACCCCACAACAGCGGGTGCATTACCCGTGCCTGCTATTTATCAACAACTGCTCGCTTTCCTGCTGGAGCA
CCACTACGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGGCGATTGCACAACAGATTGAACAAGGGATTTCAG
TGGGCGATACCATTAATGCATTGGTTGATAAATATGTATTAGTGCGAATTGGTCGTAACGGGTTCAGCGCACTGGCGCAA
GACCCGATGTTGAGCAAGGGCGATATCGTGCGGGCTCGCCAGGCTGCGGGTCTGTGGCGTGCGCATTTTCCGCCAATGTT
GCTGTACCCAACCGAGTCCCTCAATCCTATTCCACAGAGACCGTTAACATGA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12128.83 Da
• Isoelectric Point: 7.4737

>AT46197 WP_025382933.1 NZ_CP007230:2918644-2918976 [Yersinia similis]
MNNHMTTSPTWGLKRDITPRLEARLVQEGTHLHFLSDRAHIVGTFSLEATQALDAAFPALITKLESQLLSGALDPRRQQG
ITVRHGGFVCDADTLGSHGYLYIAVYQKLA

Nucleotide

• Length: 333 bp

>AT46197 NZ_CP007230:2918644-2918976 [Yersinia similis]
ATGAATAACCACATGACTACTTCCCCAACATGGGGCCTGAAACGTGACATTACGCCACGTTTGGAAGCCAGACTGGTGCA
GGAAGGAACGCATCTGCATTTTCTGAGCGACAGAGCCCACATTGTCGGCACCTTTTCCCTTGAAGCCACTCAGGCTCTTG
ATGCAGCGTTTCCCGCGCTGATAACCAAACTGGAATCGCAGTTGCTGTCCGGGGCGCTGGATCCACGCCGTCAGCAAGGC
ATTACGGTTCGGCACGGGGGATTTGTCTGTGACGCCGATACGCTGGGCAGTCACGGTTACCTCTATATCGCGGTGTATCA
GAAACTGGCTTGA