Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2819399..2820019 Replicon chromosome
Accession NZ_CP007230
Organism Yersinia similis strain Y_sim_228

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag BF17_RS12590 Protein ID WP_002208622.1
Coordinates 2819399..2819602 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0T9PQI8
Locus tag BF17_RS12595 Protein ID WP_025382853.1
Coordinates 2819651..2820019 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BF17_RS12560 2814437..2814775 + 339 WP_025382847.1 P-II family nitrogen regulator -
BF17_RS12565 2814815..2816104 + 1290 WP_038402569.1 ammonium transporter AmtB -
BF17_RS12570 2816344..2817204 - 861 WP_025382849.1 acyl-CoA thioesterase II -
BF17_RS12575 2817461..2817982 + 522 WP_025382850.1 YbaY family lipoprotein -
BF17_RS12580 2818129..2818518 - 390 WP_025382851.1 MGMT family protein -
BF17_RS12590 2819399..2819602 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
BF17_RS12595 2819651..2820019 - 369 WP_025382853.1 Hha toxicity modulator TomB Antitoxin
BF17_RS12600 2820178..2820531 - 354 WP_025382854.1 hypothetical protein -
BF17_RS12605 2821376..2821519 - 144 WP_038402146.1 type B 50S ribosomal protein L36 -
BF17_RS12610 2821535..2821795 - 261 WP_025382855.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T46196 WP_002208622.1 NZ_CP007230:c2819602-2819399 [Yersinia similis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T46196 NZ_CP007230:c2819602-2819399 [Yersinia similis]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGTTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCAGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTTTGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.98 Da        Isoelectric Point: 4.5221

>AT46196 WP_025382853.1 NZ_CP007230:c2820019-2819651 [Yersinia similis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSELSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT46196 NZ_CP007230:c2820019-2819651 [Yersinia similis]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAGCTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCGACATCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCGAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGCAGTTATGGAATCAATGATCCTGAATTGCGTCGTTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9PQI8

References