Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 2573656..2575339 Replicon chromosome
Accession NZ_CP007230
Organism Yersinia similis strain Y_sim_228

Toxin (Protein)


Gene name mosT Uniprot ID A0A0T9RSP4
Locus tag BF17_RS11525 Protein ID WP_025382679.1
Coordinates 2574422..2575339 (+) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A0T9RSP2
Locus tag BF17_RS11520 Protein ID WP_025382678.1
Coordinates 2573656..2574429 (+) Length 258 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BF17_RS11495 2568761..2569006 + 246 WP_025382675.1 hypothetical protein -
BF17_RS11500 2568978..2570705 + 1728 WP_025382676.1 DUF2326 domain-containing protein -
BF17_RS11505 2571089..2571763 - 675 Protein_2205 IS66 family transposase -
BF17_RS11515 2571931..2573042 + 1112 WP_144236056.1 IS3 family transposase -
BF17_RS11520 2573656..2574429 + 774 WP_025382678.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
BF17_RS11525 2574422..2575339 + 918 WP_025382679.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
BF17_RS11530 2576409..2576864 - 456 WP_025382680.1 ribose 5-phosphate isomerase B -
BF17_RS11535 2577347..2578462 + 1116 WP_025382681.1 alcohol dehydrogenase catalytic domain-containing protein -
BF17_RS11540 2578513..2579283 + 771 WP_025382682.1 D-threitol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(96-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34341.44 Da        Isoelectric Point: 4.7605

>T46195 WP_025382679.1 NZ_CP007230:2574422-2575339 [Yersinia similis]
MDKQSPYYRQVALLLSALPVVASERCFALKGGTAINLFVRDFPRLSVDIDLAYILLESRDVALPNVRAALTRIAEILQQQ
AGISAVLQTNNPDEMRIVVSSQEAQIKIEVSPVARGTLYPPEERDVVESVEDEFGFAAIQVVSLADLYGGKLCAALDRQH
PRDFYDVKMLLETQGIDRQIFNGFITYLLGHPRPVSEVLNPRWKDISELYANEFNGMTFDAVSLEELNAIPNLMVTALKA
QFTQQDYDFLMSFKSGQPDWSLAPEDQIQHLPAVKWKLQNIGRIPKDKHIQALAKLEAVLAEWIR

Download         Length: 918 bp

>T46195 NZ_CP007230:2574422-2575339 [Yersinia similis]
ATGGATAAGCAATCACCTTATTATCGGCAAGTTGCATTGCTGCTTAGCGCATTACCTGTTGTGGCATCAGAGAGATGCTT
TGCGCTAAAAGGTGGAACGGCAATAAACTTGTTTGTCCGTGATTTTCCACGTCTATCGGTTGATATCGATTTGGCTTACA
TTCTGCTGGAAAGCAGAGATGTGGCATTGCCAAACGTTCGGGCTGCTTTGACGCGCATTGCTGAAATACTGCAACAACAG
GCTGGCATTTCGGCGGTACTACAAACGAATAATCCTGATGAAATGCGCATTGTTGTTTCTTCTCAGGAAGCACAGATAAA
GATAGAAGTTTCGCCTGTTGCGCGAGGTACGCTGTATCCCCCAGAAGAACGTGATGTTGTTGAATCGGTAGAAGACGAGT
TCGGTTTCGCTGCTATTCAGGTTGTATCGCTTGCCGACCTCTATGGTGGCAAGCTTTGTGCTGCGCTGGATAGGCAACAT
CCCCGTGATTTTTATGACGTCAAAATGCTGCTCGAAACGCAAGGTATTGATCGCCAGATTTTTAATGGTTTCATCACCTA
TCTGCTAGGACACCCGCGCCCAGTATCAGAGGTACTTAATCCCCGCTGGAAAGATATTTCTGAGCTGTATGCGAATGAAT
TTAATGGAATGACATTCGATGCGGTCTCTCTGGAAGAACTCAATGCGATACCTAACTTAATGGTTACAGCTCTCAAAGCA
CAATTTACGCAGCAGGATTATGATTTTTTGATGTCTTTCAAAAGTGGTCAACCGGACTGGAGTCTGGCTCCTGAAGATCA
AATTCAGCACCTACCAGCGGTTAAGTGGAAGTTGCAAAATATTGGGCGCATACCAAAAGATAAACATATTCAGGCGTTGG
CGAAGCTTGAGGCGGTTCTTGCCGAGTGGATAAGATAG

Antitoxin


Download         Length: 258 a.a.        Molecular weight: 29071.51 Da        Isoelectric Point: 9.9459

>AT46195 WP_025382678.1 NZ_CP007230:2573656-2574429 [Yersinia similis]
MASKLNWLLQNTAPGSLVLQSWLTKNGISPSLANKYMHSDWLQKMRAGVYVRSGREPQWRDAVLCLQNQLGISVHLAGLT
SLTYQGRSHYLHLTRQAIWLCVDEKASLPKWFKEFPNVEWLLLSNQKLNMHDEKYLTEVEIKGERFKASVPELAAYEIAN
AVPGSLSFEHAAELFQGLVNLSPRKVEVLMQSSRAVKTNRLYLFLADHYAHAWVKRIDKANIDLGAGKRQIVSGGKLDQK
YQITVPESFVSKGISHG

Download         Length: 774 bp

>AT46195 NZ_CP007230:2573656-2574429 [Yersinia similis]
ATGGCTTCAAAACTAAACTGGCTTTTGCAGAACACTGCGCCAGGCTCCTTGGTACTACAGTCCTGGCTGACAAAAAATGG
CATAAGTCCTTCTTTAGCCAATAAGTATATGCACAGCGACTGGTTGCAAAAAATGCGTGCCGGTGTATATGTGCGGAGTG
GGCGTGAACCTCAGTGGCGTGATGCCGTTTTATGCTTGCAAAATCAGCTGGGGATTTCTGTGCATCTGGCGGGGCTTACT
AGCCTGACCTATCAGGGACGCTCTCATTATCTTCACTTAACGCGTCAGGCAATTTGGCTTTGCGTAGATGAAAAAGCTTC
GTTGCCAAAGTGGTTCAAAGAATTTCCCAATGTGGAGTGGCTTTTACTTTCTAATCAGAAGCTCAATATGCATGACGAAA
AGTATCTGACAGAGGTAGAAATTAAGGGAGAGCGGTTTAAAGCGAGTGTACCGGAATTAGCTGCTTACGAGATTGCTAAC
GCAGTCCCTGGTTCGCTTTCATTTGAGCACGCTGCGGAGCTGTTTCAGGGGCTGGTAAACCTGAGTCCACGCAAAGTCGA
AGTGTTGATGCAATCCAGCCGAGCAGTGAAAACTAACCGCCTTTACCTGTTTCTGGCCGATCACTATGCTCATGCATGGG
TTAAGCGAATAGATAAAGCCAATATTGATTTAGGCGCCGGGAAACGGCAGATCGTGTCTGGTGGCAAGCTGGACCAAAAA
TATCAGATCACTGTTCCAGAGAGTTTTGTTAGCAAAGGGATCTCACATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9RSP4

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9RSP2

References