Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1713919..1714556 Replicon chromosome
Accession NZ_CP007230
Organism Yersinia similis strain Y_sim_228

Toxin (Protein)


Gene name vapC Uniprot ID A0A0T9RF02
Locus tag BF17_RS07640 Protein ID WP_025382052.1
Coordinates 1714152..1714556 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0T9QJI8
Locus tag BF17_RS07635 Protein ID WP_005170066.1
Coordinates 1713919..1714152 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BF17_RS07615 1709371..1710435 + 1065 WP_025382048.1 bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada -
BF17_RS07620 1710503..1711879 - 1377 WP_025382049.1 envelope stress sensor histidine kinase CpxA -
BF17_RS07625 1711876..1712574 - 699 WP_025382050.1 envelope stress response regulator transcription factor CpxR -
BF17_RS07630 1712748..1713233 + 486 WP_025382051.1 cell-envelope stress modulator CpxP -
BF17_RS25715 1713410..1713535 - 126 Protein_1485 site-specific integrase -
BF17_RS07635 1713919..1714152 + 234 WP_005170066.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BF17_RS07640 1714152..1714556 + 405 WP_025382052.1 tRNA(fMet)-specific endonuclease VapC Toxin
BF17_RS07645 1714810..1715712 + 903 WP_025382053.1 CDF family cation-efflux transporter FieF -
BF17_RS07650 1715931..1716914 + 984 WP_025382054.1 6-phosphofructokinase -
BF17_RS07655 1717132..1718121 + 990 WP_025382055.1 sulfate ABC transporter substrate-binding protein -
BF17_RS07660 1718319..1719086 - 768 WP_025382056.1 triose-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14954.23 Da        Isoelectric Point: 7.4205

>T46194 WP_025382052.1 NZ_CP007230:1714152-1714556 [Yersinia similis]
MHKYMLDTNIVIYVIKCRPIEVLGRFNANTGRMVISSITLAELLHGVEKSTAPERNLNVVEDFISRLTVLNYDDKAAIHY
GSIRASLEQKGTPIGVNDLHIAGHARSTGLILVTNNRKEFDRVPGLIVDNWLGE

Download         Length: 405 bp

>T46194 NZ_CP007230:1714152-1714556 [Yersinia similis]
ATGCATAAGTACATGCTCGATACGAATATCGTTATATATGTCATTAAATGCCGGCCTATAGAAGTGTTAGGCCGGTTTAA
CGCTAATACTGGCAGAATGGTTATTTCTTCCATCACACTTGCTGAGTTGTTGCATGGTGTAGAGAAAAGTACGGCACCTG
AACGCAATTTGAATGTTGTAGAGGACTTTATTTCACGCCTTACTGTACTGAATTATGACGATAAAGCTGCAATTCACTAT
GGTTCTATACGTGCAAGTCTGGAGCAAAAAGGGACACCCATTGGTGTTAATGATTTACATATCGCAGGTCATGCCAGAAG
CACTGGATTAATATTAGTGACGAATAACCGCAAAGAATTTGATCGTGTGCCTGGACTCATTGTCGACAACTGGTTAGGAG
AATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8978.95 Da        Isoelectric Point: 5.0351

>AT46194 WP_005170066.1 NZ_CP007230:1713919-1714152 [Yersinia similis]
MSQGTIFTNNRTQNVRLPVDMRFPENVKSVTVRAVGNERILSPVENSWDSFFFSSPRVSDDFLTERAEQHQSERELF

Download         Length: 234 bp

>AT46194 NZ_CP007230:1713919-1714152 [Yersinia similis]
ATGTCACAGGGCACCATTTTTACAAACAATCGTACTCAAAATGTACGTTTACCGGTGGATATGCGCTTTCCGGAGAATGT
TAAATCAGTGACTGTCAGAGCTGTAGGGAATGAGCGTATTTTGTCACCCGTTGAAAACTCTTGGGATAGTTTTTTCTTCA
GTAGTCCGCGTGTTTCAGACGATTTTCTGACAGAACGTGCAGAACAGCATCAATCAGAGCGTGAGTTATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9RF02

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9QJI8

References