Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1552620..1553173 Replicon chromosome
Accession NZ_CP007230
Organism Yersinia similis strain Y_sim_228

Toxin (Protein)


Gene name ccdB Uniprot ID A0A0T9QCQ4
Locus tag BF17_RS06855 Protein ID WP_025381929.1
Coordinates 1552620..1552934 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0T9QCR9
Locus tag BF17_RS06860 Protein ID WP_025381930.1
Coordinates 1552937..1553173 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BF17_RS06835 1548031..1549980 + 1950 WP_025381925.1 methyl-accepting chemotaxis protein -
BF17_RS06840 1550480..1550812 + 333 WP_025381926.1 hypothetical protein -
BF17_RS06845 1551316..1551792 + 477 WP_025381927.1 DM13 domain-containing protein -
BF17_RS06850 1551957..1552313 - 357 WP_025381928.1 YibL family ribosome-associated protein -
BF17_RS06855 1552620..1552934 - 315 WP_025381929.1 CcdB family protein Toxin
BF17_RS06860 1552937..1553173 - 237 WP_025381930.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
BF17_RS24910 1553207..1553350 - 144 WP_071825452.1 gluconate 5-dehydrogenase -
BF17_RS25490 1553449..1553619 + 171 WP_162471853.1 hypothetical protein -
BF17_RS06865 1553620..1554174 - 555 WP_025381931.1 MltR family transcriptional regulator -
BF17_RS06870 1554378..1555541 - 1164 WP_025381932.1 mannitol-1-phosphate 5-dehydrogenase -
BF17_RS06875 1555678..1557609 - 1932 WP_025381933.1 PTS mannitol transporter subunit IICBA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11440.42 Da        Isoelectric Point: 6.9187

>T46193 WP_025381929.1 NZ_CP007230:c1552934-1552620 [Yersinia similis]
MQFTVYCNTGKSVAYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPGGNRPDRMIPLIRLTDGKEYAVMTHELASIPVRALG
AEFCGAAQYCTQVKAAIDFLLDGI

Download         Length: 315 bp

>T46193 NZ_CP007230:c1552934-1552620 [Yersinia similis]
ATGCAATTCACTGTCTACTGTAATACCGGAAAAAGCGTCGCTTACCCCCTGTTACTTGATGTAACGAGCGACATTATCGG
ACAACTAAATCGTCGAATTGTAATCCCGCTGTTACCTGTTGAAAAATATCCGGGCGGCAATCGTCCAGATCGAATGATTC
CCCTTATTAGGCTGACAGACGGCAAAGAATACGCAGTAATGACTCACGAACTGGCAAGTATACCTGTTCGCGCTCTGGGG
GCAGAGTTCTGCGGCGCGGCGCAATATTGTACACAGGTAAAAGCGGCAATAGATTTTCTTCTTGATGGAATTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8958.90 Da        Isoelectric Point: 6.0711

>AT46193 WP_025381930.1 NZ_CP007230:c1553173-1552937 [Yersinia similis]
MAAKQRNTQNVTMTVERDLLSRAREAGINLSATLAAALDAELRHHATRKWQEENTEALEALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT46193 NZ_CP007230:c1553173-1552937 [Yersinia similis]
ATGGCAGCCAAACAACGCAATACACAGAACGTCACAATGACTGTAGAGCGAGACTTACTAAGCAGGGCGCGTGAGGCCGG
TATTAACCTTAGCGCTACCCTGGCGGCCGCTCTAGATGCCGAACTACGTCATCACGCAACGAGAAAATGGCAGGAAGAGA
ACACGGAAGCCCTTGAGGCATTAAATCGTTTCCATGATGAACATGGTTGCTTCAGCGATGAATACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9QCQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9QCR9

References