Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 877456..878156 Replicon chromosome
Accession NZ_CP007230
Organism Yersinia similis strain Y_sim_228

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag BF17_RS03905 Protein ID WP_025381469.1
Coordinates 877785..878156 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag BF17_RS03900 Protein ID WP_025381468.1
Coordinates 877456..877788 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BF17_RS03860 872521..872742 - 222 WP_025381462.1 hypothetical protein -
BF17_RS03865 872735..872929 - 195 WP_038402409.1 host cell division inhibitor Icd-like protein -
BF17_RS23200 873072..873257 + 186 WP_071825436.1 toxin-antitoxin system HicB family antitoxin -
BF17_RS03875 873502..873849 - 348 WP_025381463.1 hypothetical protein -
BF17_RS03880 873858..874058 - 201 WP_025381464.1 helix-turn-helix domain-containing protein -
BF17_RS24405 874160..874816 - 657 WP_025381465.1 hypothetical protein -
BF17_RS03890 874813..876225 - 1413 WP_025381466.1 integrase family protein -
BF17_RS03895 876517..877371 - 855 WP_025381467.1 DUF4942 domain-containing protein -
BF17_RS03900 877456..877788 - 333 WP_025381468.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BF17_RS03905 877785..878156 - 372 WP_025381469.1 TA system toxin CbtA family protein Toxin
BF17_RS03910 878237..878569 - 333 WP_049870163.1 hypothetical protein -
BF17_RS03915 878563..879036 - 474 WP_038402413.1 DNA repair protein RadC -
BF17_RS03920 879069..879500 - 432 WP_025381470.1 antirestriction protein -
BF17_RS03925 879726..880052 - 327 WP_025381471.1 DUF932 domain-containing protein -
BF17_RS03930 880149..880616 - 468 WP_025381472.1 hypothetical protein -
BF17_RS03935 880718..881254 - 537 WP_025381473.1 DUF4339 domain-containing protein -
BF17_RS03940 881377..881997 - 621 WP_025381474.1 hypothetical protein -
BF17_RS03945 882003..882704 - 702 WP_025381475.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(7-101)

Antitoxin

Antitoxin CbeA

(9-108)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13680.74 Da        Isoelectric Point: 7.3983

>T46192 WP_025381469.1 NZ_CP007230:c878156-877785 [Yersinia similis]
MKPRPTSPGALPVPVIYQQLLAFLLEHHYGLSLNDTPYHDEQVITQQIEQGISVGDTINTLVEKYALVRIGRNGFSALAQ
DPMLSKGDIVRARQAAGLWRAHFPPTLLYPTESLNPIPQRPLT

Download         Length: 372 bp

>T46192 NZ_CP007230:c878156-877785 [Yersinia similis]
ATGAAACCACGACCCACCTCACCAGGCGCATTGCCCGTGCCTGTTATTTATCAACAACTGCTCGCTTTCCTGCTGGAACA
CCACTATGGCCTGAGCCTCAACGATACGCCTTATCACGATGAACAGGTGATTACACAACAGATAGAACAAGGGATTTCAG
TCGGCGACACCATCAACACACTGGTTGAGAAATATGCCTTAGTGCGAATTGGTCGTAACGGGTTCAGCGCACTGGCGCAA
GACCCGATGTTGAGCAAGGGCGATATCGTGCGGGCTCGCCAGGCTGCTGGCCTGTGGCGGGCTCATTTTCCACCCACATT
GCTGTACCCAACCGAGTCCCTCAATCCTATTCCACAGAGACCGTTAACATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12197.85 Da        Isoelectric Point: 7.0601

>AT46192 WP_025381468.1 NZ_CP007230:c877788-877456 [Yersinia similis]
MNNHMTTSPTWGLKRDITPRLGARLVQEGTHLHFLSDRAHIVGTFSPQAAQALDVAFPALITKLESQLLSGQLDPRRQQG
ITVRHGEFVCEADTLGSHGYLYIAVYQELS

Download         Length: 333 bp

>AT46192 NZ_CP007230:c877788-877456 [Yersinia similis]
ATGAATAACCACATGACTACTTCCCCAACATGGGGCCTGAAACGTGATATTACGCCGCGGTTGGGGGCCCGACTGGTTCA
GGAGGGAACGCATCTGCATTTTCTGAGCGACAGAGCCCACATTGTCGGCACCTTTTCCCCTCAAGCCGCTCAGGCTCTTG
ATGTGGCATTCCCAGCGCTGATAACCAAACTGGAGTCGCAGTTGCTGTCCGGTCAGCTTGACCCTCGCCGTCAGCAAGGC
ATTACGGTTCGGCATGGAGAATTTGTCTGTGAAGCGGATACGCTGGGCAGTCACGGTTACCTCTATATCGCGGTGTATCA
GGAACTGTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References