46191

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 551517..552560 Replicon chromosome
Accession NZ_CP007230
Organism Yersinia similis strain Y_sim_228

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag BF17_RS02545 Protein ID WP_025381226.1
Coordinates 551985..552560 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag BF17_RS02540 Protein ID WP_025381225.1
Coordinates 551517..551981 (+) Length 155 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BF17_RS02520 546717..548786 - 2070 WP_025381222.1 type IV conjugative transfer system coupling protein TraD -
BF17_RS02525 548929..549465 - 537 WP_048677822.1 integrating conjugative element protein -
BF17_RS02530 549462..550124 - 663 WP_081761358.1 TIGR03759 family integrating conjugative element protein -
BF17_RS02535 550400..551092 - 693 WP_038401994.1 TIGR03761 family integrating conjugative element protein -
BF17_RS02540 551517..551981 + 465 WP_025381225.1 helix-turn-helix domain-containing protein Antitoxin
BF17_RS02545 551985..552560 + 576 WP_025381226.1 PIN domain-containing protein Toxin
BF17_RS02550 552687..552887 - 201 WP_025381227.1 DUF1845 family protein -
BF17_RS02555 553043..553669 - 627 WP_025381228.1 hypothetical protein -
BF17_RS25685 553747..554538 - 792 Protein_497 type VI secretion protein ImpA -
BF17_RS24765 554533..555444 - 912 Protein_498 type VI secretion protein VasK -
BF17_RS02565 555621..556838 - 1218 WP_025381230.1 hypothetical protein -
BF17_RS02570 556841..557104 - 264 WP_025381231.1 PAAR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-114)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21910.52 Da        Isoelectric Point: 6.4921

>T46191 WP_025381226.1 NZ_CP007230:551985-552560 [Yersinia similis]
MKHSPYPVVLDACVLYPARLRDLLMHLGLAGLYQPKWSDTIQDEWRRNLLIQRSDIKPEALVHTTRLMNRALPDANVTGY
ERLIEGLKLPDRDDRHVLATAIRAKAEVIVTMNLRDFPPDILTEFGIEALHPDEFISDLFDLNHAIALDAVRQQRKSLKN
PPMTTDEFLDMLLKQGLPMTIKALDGYRCMI

Download         Length: 576 bp

>T46191 NZ_CP007230:551985-552560 [Yersinia similis]
ATGAAACACTCCCCCTATCCAGTGGTACTTGATGCATGTGTTCTGTATCCAGCAAGATTGCGCGACTTGCTGATGCATTT
AGGCCTTGCTGGCTTGTACCAGCCCAAATGGTCAGACACTATTCAAGATGAGTGGCGGCGCAATCTCCTAATACAGCGTA
GCGATATAAAACCTGAAGCTTTGGTACATACAACGAGACTAATGAATCGGGCTTTACCTGATGCCAATGTCACAGGATAT
GAACGACTAATTGAAGGGCTAAAATTACCTGATCGAGATGATCGCCATGTATTGGCCACGGCTATACGGGCAAAGGCTGA
AGTTATTGTTACGATGAATTTAAGAGATTTCCCGCCCGATATTTTGACTGAATTTGGTATTGAAGCACTTCATCCAGATG
AGTTTATTTCTGATCTTTTCGATTTAAACCATGCAATTGCATTAGATGCAGTCAGGCAGCAACGTAAGTCATTAAAAAAT
CCACCGATGACTACTGATGAATTTTTAGACATGCTGTTAAAGCAGGGGTTGCCCATGACGATCAAGGCACTTGATGGTTA
TCGGTGTATGATTTAG

Antitoxin


Download         Length: 155 a.a.        Molecular weight: 17014.56 Da        Isoelectric Point: 6.2237

>AT46191 WP_025381225.1 NZ_CP007230:551517-551981 [Yersinia similis]
MTNTSLTGLNLPAKHEIEIATRGQRELAAFLSTKLETQQISIKDADNVSHQIELPTSALTMLMDVLGELAAGNAVQVVPI
HAELTTQEAANIMNVSRPHMVKLLEEGQLPYHKTGRHRRILFADLMEYKKKRDADSLVAMQELAAQAQELGLGY

Download         Length: 465 bp

>AT46191 NZ_CP007230:551517-551981 [Yersinia similis]
ATGACCAATACCAGCCTGACCGGTCTAAATCTTCCGGCAAAACATGAGATTGAAATCGCAACGCGAGGCCAACGAGAGCT
AGCAGCATTTCTTTCCACAAAATTAGAGACTCAACAAATCTCCATTAAAGATGCGGATAACGTATCGCACCAAATTGAGC
TTCCTACCTCAGCCTTAACCATGCTGATGGATGTTCTTGGTGAGCTGGCAGCAGGTAATGCTGTGCAGGTTGTGCCGATA
CATGCGGAACTGACTACGCAAGAAGCGGCAAATATAATGAATGTATCTCGCCCTCATATGGTCAAATTGTTGGAAGAAGG
ACAACTGCCTTATCATAAAACAGGGCGGCATCGTCGAATTCTGTTCGCTGACTTGATGGAATACAAAAAGAAACGTGATG
CAGATAGCTTGGTTGCTATGCAAGAGCTTGCTGCTCAGGCACAGGAACTTGGGTTGGGCTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References