Detailed information of TA system TA046190

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 537220..537883
• Replicon: chromosome
• Accession: NZ_CP007230
• Organism: Yersinia similis strain Y_sim_228

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: BF17_RS02455
• Protein ID: WP_025381209.1
• Coordinates: 537220..537564 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: BF17_RS02460
• Protein ID: WP_025381210.1
• Coordinates: 537566..537883 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BF17_RS02435	532920..533342	-	423	WP_025381205.1	antirestriction protein	-
BF17_RS02440	533697..534593	-	897	WP_025381206.1	integrase domain-containing protein	-
BF17_RS02445	535903..536823	-	921	WP_025381207.1	Rpn family recombination-promoting nuclease/putative transposase	-
BF17_RS25295	536904..537245	+	342	WP_158499225.1	hypothetical protein	-
BF17_RS02455	537220..537564	+	345	WP_025381209.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BF17_RS02460	537566..537883	+	318	WP_025381210.1	helix-turn-helix domain-containing protein	Antitoxin
BF17_RS25525	537955..538125	-	171	WP_167330747.1	hypothetical protein	-
BF17_RS02465	538266..538472	+	207	WP_025381211.1	host cell division inhibitor Icd-like protein	-
BF17_RS02470	538462..538794	+	333	WP_025381212.1	hypothetical protein	-
BF17_RS02475	539519..539737	+	219	WP_025381213.1	hypothetical protein	-
BF17_RS02480	539776..541287	-	1512	WP_025381214.1	conjugal transfer protein TraG N-terminal domain-containing protein	-
BF17_RS02485	541287..541637	-	351	WP_025381215.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	pilW / pilW / pilV / pilU / pilS / pilR / pilQ / pilP / pilO / pilN / pilM / pilL / pilW	486498..545802	59304
	-	flank	IS/Tn	-	pilW	535903..536823	920

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (35-86)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12488.28 Da
• Isoelectric Point: 9.5494

>T46190 WP_025381209.1 NZ_CP007230:537220-537564 [Yersinia similis]
MKPLYWVGSSKKDLQSLPEDVQDIFGYGLHLAQMGSKHSQAKPLKGFGGAGVLEVVEDYIGDTYRAVYTVKFGDAVYVLH
AFQKKSSSGIATPKPDMDKIRERLKTAESHAKGA

Nucleotide

• Length: 345 bp

>T46190 NZ_CP007230:537220-537564 [Yersinia similis]
ATGAAGCCACTTTATTGGGTTGGTAGCAGTAAAAAGGATCTTCAGTCTCTACCTGAAGATGTACAAGATATTTTCGGCTA
CGGCCTGCATTTGGCACAGATGGGCAGTAAACATTCCCAAGCGAAGCCCTTGAAAGGGTTTGGTGGCGCAGGTGTACTGG
AAGTTGTTGAGGATTACATCGGTGACACCTACCGAGCGGTTTATACCGTCAAATTTGGTGATGCGGTGTATGTTTTACAT
GCATTTCAGAAAAAATCCTCATCGGGAATAGCTACGCCAAAACCAGATATGGATAAGATCCGCGAACGGTTGAAAACCGC
AGAAAGCCATGCTAAAGGAGCATAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11555.48 Da
• Isoelectric Point: 10.6107

>AT46190 WP_025381210.1 NZ_CP007230:537566-537883 [Yersinia similis]
MSHDIEISSGNVYADLGKDNAEEMQVKAQLATTIGNIIKSRRLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSLKVVFA

Nucleotide

• Length: 318 bp

>AT46190 NZ_CP007230:537566-537883 [Yersinia similis]
ATGAGCCATGATATCGAAATCAGCAGCGGCAATGTTTATGCCGATCTTGGCAAAGATAATGCTGAAGAAATGCAGGTAAA
AGCGCAACTCGCTACCACCATTGGCAACATTATTAAAAGCCGTCGCCTCACACAAGAACAGGCCGCTAAACTGCTCGGAA
TGACTCAGCCTAAGCTGTCTAATATGTTACGTGGGCAGTTCAGGGGGATCAGCGAGGCCAAAATGTTGGAATGCCTGACT
CGTTTGGGGCGTGATGTGCAAATTGTCGTTGGGAAACCACGTCGCACACCTGGTAGCCTGAAAGTTGTATTTGCCTGA