Detailed information of TA system TA046189

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 386769..387441
• Replicon: chromosome
• Accession: NZ_CP007230
• Organism: Yersinia similis strain Y_sim_228

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: BF17_RS01785
• Protein ID: WP_025381103.1
• Coordinates: 386769..387194 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A0T9RDV7
• Locus tag: BF17_RS01790
• Protein ID: WP_025381104.1
• Coordinates: 387175..387441 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BF17_RS01765	382468..382986	+	519	WP_002209934.1	flavodoxin FldB	-
BF17_RS01770	383071..384528	-	1458	WP_038401985.1	cell envelope integrity protein CreD	-
BF17_RS01775	384628..386046	-	1419	WP_025381101.1	two-component system sensor histidine kinase CreC	-
BF17_RS01780	386071..386769	-	699	WP_025381102.1	two-component system response regulator CreB	-
BF17_RS01785	386769..387194	-	426	WP_025381103.1	protein YgfX	Toxin
BF17_RS01790	387175..387441	-	267	WP_025381104.1	FAD assembly factor SdhE	Antitoxin
BF17_RS01795	387758..388749	+	992	Protein_341	tRNA-modifying protein YgfZ	-
BF17_RS01800	388825..389319	-	495	WP_025381105.1	DUF2165 family protein	-
BF17_RS01805	389594..390295	-	702	WP_025381106.1	hemolysin III family protein	-
BF17_RS25680	390424..390618	-	195	WP_025381107.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-133)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 16446.30 Da
• Isoelectric Point: 10.1175

>T46189 WP_025381103.1 NZ_CP007230:c387194-386769 [Yersinia similis]
VAQWRCNLRVSWHTQLFSLLAHGVLAILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVLWKRH
EWNVVKQPWITRYGVLLNLQQTGGHTARKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Nucleotide

• Length: 426 bp

>T46189 NZ_CP007230:c387194-386769 [Yersinia similis]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCGCACGGTGTATTGGCTAT
TTTAACCTTGGTCGCGCCCTGGCCCTTAGGTTATACCGCCCTATGGCTGGTATTGCTGACGCTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCTATGGAAAAGGCAT
GAATGGAACGTGGTCAAGCAGCCGTGGATCACCCGCTATGGGGTATTATTAAATTTACAACAAACAGGCGGCCACACGGC
CCGAAAGCGCCTATGGTTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTACTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10510.99 Da
• Isoelectric Point: 4.8306

>AT46189 WP_025381104.1 NZ_CP007230:c387441-387175 [Yersinia similis]
MEINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT46189 NZ_CP007230:c387441-387175 [Yersinia similis]
ATGGAAATTAATAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGTTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCATGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0T9RDV7