Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4295754..4296270 Replicon chromosome
Accession NZ_CP007215
Organism Kosakonia sacchari SP1

Toxin (Protein)


Gene name relE Uniprot ID A0A1G4YUH3
Locus tag C813_RS43300 Protein ID WP_017459098.1
Coordinates 4295754..4296038 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1G4YUC9
Locus tag C813_RS43305 Protein ID WP_017459099.1
Coordinates 4296028..4296270 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C813_RS43285 4290921..4292576 + 1656 WP_017459095.1 alpha,alpha-phosphotrehalase -
C813_RS43290 4292961..4295096 + 2136 WP_017459096.1 anaerobic ribonucleoside-triphosphate reductase -
C813_RS43295 4295284..4295748 + 465 WP_017459097.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
C813_RS43300 4295754..4296038 - 285 WP_017459098.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C813_RS43305 4296028..4296270 - 243 WP_017459099.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C813_RS43310 4296363..4297283 - 921 WP_017459100.1 AraC family transcriptional regulator -
C813_RS43315 4297388..4298221 + 834 WP_025263745.1 oxidoreductase -
C813_RS43320 4298256..4300166 - 1911 WP_017459102.1 BglG family transcription antiterminator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-75)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11047.02 Da        Isoelectric Point: 10.7335

>T46185 WP_017459098.1 NZ_CP007215:c4296038-4295754 [Kosakonia sacchari SP1]
MNYELVFDPRAYKEWKKLGATVKTQFKKKLAAVLVQPRIEKTRLHQFPDCYKIKLRSSGYRLVYQVRDHVVTVFVVSIGK
REKAAAYQDASKRL

Download         Length: 285 bp

>T46185 NZ_CP007215:c4296038-4295754 [Kosakonia sacchari SP1]
ATGAATTATGAGCTGGTGTTTGATCCCCGCGCATACAAAGAATGGAAAAAACTCGGTGCCACGGTAAAAACACAGTTCAA
AAAGAAACTGGCGGCTGTGCTGGTTCAACCCAGAATTGAAAAGACCCGACTGCATCAATTTCCGGATTGCTACAAGATCA
AATTGCGATCATCAGGCTACCGGTTGGTCTATCAGGTCAGAGACCATGTGGTGACGGTATTCGTTGTGTCTATCGGTAAA
CGCGAAAAAGCCGCCGCTTATCAGGATGCCAGCAAGCGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9176.65 Da        Isoelectric Point: 4.8409

>AT46185 WP_017459099.1 NZ_CP007215:c4296270-4296028 [Kosakonia sacchari SP1]
MATLNVRLDDKLKEEAWRVLEKLNITPTEAVRLLFQYVAENGRMPIKTVTVSEDESALLEIVRERLANPQKGIKVNLDEL

Download         Length: 243 bp

>AT46185 NZ_CP007215:c4296270-4296028 [Kosakonia sacchari SP1]
ATGGCGACGCTAAATGTTCGACTGGATGACAAACTCAAAGAAGAGGCCTGGCGCGTGCTGGAAAAACTCAATATCACCCC
AACCGAAGCCGTTCGCTTACTGTTCCAATATGTCGCTGAAAACGGGCGTATGCCGATCAAAACAGTGACGGTGAGCGAGG
ACGAATCGGCGTTGCTGGAGATTGTCCGGGAGCGCCTGGCGAACCCGCAAAAAGGCATCAAGGTTAATCTGGATGAATTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G4YUH3

Antitoxin

Source ID Structure
AlphaFold DB A0A1G4YUC9

References