Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 3171078..3171982 Replicon chromosome
Accession NZ_CP007215
Organism Kosakonia sacchari SP1

Toxin (Protein)


Gene name - Uniprot ID A0A1G4XF26
Locus tag C813_RS37930 Protein ID WP_017456166.1
Coordinates 3171518..3171982 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1G4XF96
Locus tag C813_RS37925 Protein ID WP_017456167.1
Coordinates 3171078..3171521 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C813_RS37905 3166118..3167884 + 1767 WP_017456170.1 cysteine/glutathione ABC transporter permease/ATP-binding protein CydD -
C813_RS37910 3167885..3169606 + 1722 WP_017456169.1 cysteine/glutathione ABC transporter ATP-binding protein/permease CydC -
C813_RS37915 3169713..3170414 + 702 WP_017456168.1 leucyl/phenylalanyl-tRNA--protein transferase -
C813_RS37920 3170703..3170921 + 219 WP_001040187.1 translation initiation factor IF-1 -
C813_RS37925 3171078..3171521 + 444 WP_017456167.1 DUF2384 domain-containing protein Antitoxin
C813_RS37930 3171518..3171982 + 465 WP_017456166.1 RES domain-containing protein Toxin
C813_RS46845 3171990..3172545 + 556 Protein_2958 GGDEF domain-containing protein -
C813_RS37940 3172613..3174904 - 2292 WP_017456165.1 ATP-dependent Clp protease ATP-binding subunit ClpA -
C813_RS37945 3174935..3175255 - 321 WP_017456164.1 ATP-dependent Clp protease adapter ClpS -
C813_RS37950 3175584..3175805 + 222 WP_017456163.1 cold shock-like protein CspD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-147)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(29-90)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17169.68 Da        Isoelectric Point: 6.3707

>T46181 WP_017456166.1 NZ_CP007215:3171518-3171982 [Kosakonia sacchari SP1]
VIFYRLVTRRYASEAWTGSGANLYGGRWNHKGHPAVYVASSVSLAALEMLVHVHSDTVLNQYGLFSIEIPDKDIEHLDKQ
WLPPDWHENPAPLSTMDLGTTWLEANSAVALVLPSCVIPLENNAILNPLHPAFNKLLKTVKELPFCFDPRLANA

Download         Length: 465 bp

>T46181 NZ_CP007215:3171518-3171982 [Kosakonia sacchari SP1]
GTGATCTTCTATCGACTGGTAACGCGCCGCTACGCCAGCGAAGCCTGGACAGGCAGCGGTGCAAATCTTTATGGCGGGCG
CTGGAATCACAAGGGTCATCCGGCGGTTTACGTCGCTTCGTCCGTTTCACTTGCCGCACTCGAAATGCTGGTACATGTGC
ACAGCGACACGGTTCTGAACCAGTATGGGCTGTTCAGTATTGAGATCCCTGACAAGGATATTGAACATCTGGATAAGCAA
TGGCTACCGCCAGACTGGCATGAAAACCCCGCACCGCTTTCGACAATGGATTTAGGTACCACCTGGCTGGAAGCCAACAG
CGCCGTCGCACTGGTGCTGCCGTCATGCGTTATTCCGCTTGAGAATAATGCGATTCTTAACCCGCTTCATCCTGCTTTTA
ATAAGCTGCTAAAAACCGTAAAAGAGCTTCCTTTCTGTTTCGATCCACGCCTGGCAAACGCGTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16463.92 Da        Isoelectric Point: 8.8231

>AT46181 WP_017456167.1 NZ_CP007215:3171078-3171521 [Kosakonia sacchari SP1]
MRTWSPDQKPVENALWRFAGFPANRGLKLVQMLNEGLPVSILDNIHEWTEMSRSDILRVTGINERNVARRKSAGRTLTPE
ESERIARLVRVVDAAVQFFGSKKMAWDWLETPIRGLGNVAPISLIATESGALEVTDLLGRLEHGVFA

Download         Length: 444 bp

>AT46181 NZ_CP007215:3171078-3171521 [Kosakonia sacchari SP1]
ATGAGAACCTGGAGTCCGGATCAAAAACCGGTCGAAAATGCGCTCTGGCGCTTTGCCGGTTTCCCTGCCAACCGAGGGCT
AAAACTCGTTCAGATGTTAAACGAGGGCTTGCCTGTCAGCATTCTCGACAATATTCATGAATGGACAGAAATGTCCCGCT
CCGACATTCTGCGCGTCACCGGTATTAATGAACGCAATGTCGCGCGTCGCAAAAGCGCCGGCCGCACACTCACGCCGGAA
GAAAGTGAGCGCATTGCGCGTTTGGTGAGGGTTGTTGATGCTGCGGTACAGTTTTTCGGTAGCAAAAAGATGGCGTGGGA
CTGGCTGGAAACCCCCATTCGCGGCCTTGGCAACGTAGCGCCGATTTCGCTGATTGCCACCGAAAGTGGCGCGCTGGAAG
TAACCGACCTGCTCGGCAGGCTGGAGCACGGAGTATTTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G4XF26

Antitoxin

Source ID Structure
AlphaFold DB A0A1G4XF96

References