Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1431976..1432564 Replicon chromosome
Accession NZ_CP007215
Organism Kosakonia sacchari SP1

Toxin (Protein)


Gene name relE Uniprot ID A0A1G4YIF2
Locus tag C813_RS29840 Protein ID WP_017458694.1
Coordinates 1431976..1432263 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1G4YII4
Locus tag C813_RS29845 Protein ID WP_017458693.1
Coordinates 1432325..1432564 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C813_RS29820 1427078..1428163 + 1086 WP_017458698.1 YncE family protein -
C813_RS29825 1428213..1430426 + 2214 WP_017458697.1 TonB-dependent siderophore receptor -
C813_RS29830 1430435..1431331 - 897 WP_017458696.1 LysR family transcriptional regulator -
C813_RS29835 1431428..1431952 + 525 WP_017458695.1 GNAT family N-acetyltransferase -
C813_RS29840 1431976..1432263 - 288 WP_017458694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C813_RS29845 1432325..1432564 - 240 WP_017458693.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C813_RS29850 1432641..1434050 - 1410 WP_017458692.1 glutamine synthetase family protein -
C813_RS29855 1434173..1434646 - 474 WP_017458691.1 NUDIX domain-containing protein -
C813_RS29860 1434805..1435065 + 261 WP_017458690.1 DUF2534 family protein -
C813_RS29865 1435369..1437309 + 1941 WP_017458689.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11145.09 Da        Isoelectric Point: 10.8167

>T46171 WP_017458694.1 NZ_CP007215:c1432263-1431976 [Kosakonia sacchari SP1]
MVYQLDFDQRALKEWRKLGSAVREQFKKKIAQVLKAPRIEANRLHHLPDCYKIKLRASGYRLVYQVNDGRIVVFVVSVGK
RERNTVYGIAESRLI

Download         Length: 288 bp

>T46171 NZ_CP007215:c1432263-1431976 [Kosakonia sacchari SP1]
ATGGTTTATCAACTGGATTTCGATCAACGTGCGTTAAAAGAGTGGCGAAAATTAGGCAGCGCTGTTCGCGAGCAGTTTAA
GAAGAAAATCGCTCAGGTGCTTAAAGCGCCGAGGATTGAAGCGAACAGACTCCATCATTTACCTGATTGCTACAAAATCA
AATTGCGCGCTTCAGGCTATCGTCTGGTCTACCAGGTGAATGATGGACGGATTGTGGTGTTCGTTGTCTCTGTCGGAAAA
CGCGAACGTAACACCGTGTATGGCATCGCAGAAAGTCGCCTGATATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9140.48 Da        Isoelectric Point: 5.1409

>AT46171 WP_017458693.1 NZ_CP007215:c1432564-1432325 [Kosakonia sacchari SP1]
MGNLNVRIDDDLKARSFAALEKLGVTPSELLRQTLEYVAENGKLPFHRTLLNDEDRQLIEIVRERLRDPKPVRVTLDDL

Download         Length: 240 bp

>AT46171 NZ_CP007215:c1432564-1432325 [Kosakonia sacchari SP1]
ATGGGCAATTTGAATGTTCGTATTGATGACGATTTAAAAGCGCGTTCCTTTGCCGCTCTGGAAAAACTTGGCGTAACACC
TTCCGAGCTTTTACGACAGACGCTCGAATATGTCGCCGAGAACGGCAAGCTACCGTTTCACCGCACACTGCTTAATGATG
AAGATCGGCAACTGATCGAAATCGTGCGTGAGCGTTTACGCGATCCAAAACCGGTTCGTGTGACGCTTGACGATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G4YIF2

Antitoxin

Source ID Structure
AlphaFold DB A0A1G4YII4

References