Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 863146..863706 Replicon chromosome
Accession NZ_CP007215
Organism Kosakonia sacchari SP1

Toxin (Protein)


Gene name ccdB Uniprot ID A0A1G4Y1N1
Locus tag C813_RS27090 Protein ID WP_017457648.1
Coordinates 863146..863457 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A1G4Y242
Locus tag C813_RS27095 Protein ID WP_017457649.1
Coordinates 863461..863706 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C813_RS27070 858679..859254 + 576 WP_017457644.1 ABATE domain-containing protein -
C813_RS27075 859800..860867 - 1068 WP_017457645.1 SDR family oxidoreductase -
C813_RS27080 860971..861903 + 933 WP_017457646.1 LysR family transcriptional regulator -
C813_RS27085 861968..863089 + 1122 WP_017457647.1 cupin domain-containing protein -
C813_RS27090 863146..863457 - 312 WP_017457648.1 CcdB family protein Toxin
C813_RS27095 863461..863706 - 246 WP_017457649.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
C813_RS27100 863844..864440 - 597 WP_197511314.1 nitroreductase family protein -
C813_RS27105 865323..866648 + 1326 WP_017457651.1 sensor domain-containing diguanylate cyclase -
C813_RS27110 866669..867811 - 1143 WP_017457652.1 PLP-dependent aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(11-81)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11824.56 Da        Isoelectric Point: 4.6436

>T46169 WP_017457648.1 NZ_CP007215:c863457-863146 [Kosakonia sacchari SP1]
MQYSVYRNKSNSRDFPFLLDVQSDIIGSMNSRAVIPLCPLADYKDRRRVERLNPVLEIEGESYLLLTHDLAGVSLALLGE
EVCSMRAQRDVIRNAMDFIFDEI

Download         Length: 312 bp

>T46169 NZ_CP007215:c863457-863146 [Kosakonia sacchari SP1]
ATGCAATATTCGGTTTATCGGAACAAAAGTAACAGCCGGGATTTCCCGTTTCTGCTGGATGTACAGAGCGATATTATCGG
TAGCATGAACTCACGGGCGGTGATCCCGCTCTGTCCCCTGGCGGATTACAAAGATCGCCGCCGGGTTGAGCGGTTAAATC
CGGTACTGGAGATCGAAGGGGAATCGTATTTGTTACTGACCCACGATCTCGCAGGCGTCAGCCTGGCGCTTTTGGGTGAA
GAAGTTTGCAGTATGCGCGCCCAGCGCGACGTGATCCGCAATGCGATGGATTTTATTTTTGACGAGATTTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9333.43 Da        Isoelectric Point: 7.2061

>AT46169 WP_017457649.1 NZ_CP007215:c863706-863461 [Kosakonia sacchari SP1]
MPVTATKQRNKQNVSVTVERDLLEQARKEGINLSQTLTNALQGELRNLEAERWKRENAAAIADLNEFIAERGHFSDEHRK
F

Download         Length: 246 bp

>AT46169 NZ_CP007215:c863706-863461 [Kosakonia sacchari SP1]
ATGCCTGTTACTGCAACTAAACAGCGAAACAAGCAAAATGTCAGCGTGACCGTCGAGCGCGACCTACTGGAACAAGCGCG
CAAAGAAGGCATCAACCTTTCGCAAACGCTGACGAACGCCCTGCAAGGCGAACTGCGTAATCTGGAAGCTGAGCGCTGGA
AGCGCGAAAATGCCGCCGCCATTGCCGATTTAAATGAATTTATTGCCGAACGCGGCCACTTCTCGGATGAACACAGGAAG
TTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G4Y1N1

Antitoxin

Source ID Structure
AlphaFold DB A0A1G4Y242

References