Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 597893..599574 Replicon chromosome
Accession NZ_CP007213
Organism Burkholderia plantarii strain ATCC 43733

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag bpln_RS20125 Protein ID WP_055139792.1
Coordinates 597893..599227 (-) Length 445 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag bpln_RS20130 Protein ID WP_055139793.1
Coordinates 599233..599574 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
bpln_RS20115 593071..596256 + 3186 WP_042627151.1 multidrug efflux RND transporter permease subunit -
bpln_RS20120 596268..597812 + 1545 WP_042627152.1 efflux transporter outer membrane subunit -
bpln_RS20125 597893..599227 - 1335 WP_055139792.1 type II toxin-antitoxin system HipA family toxin Toxin
bpln_RS20130 599233..599574 - 342 WP_055139793.1 helix-turn-helix domain-containing protein Antitoxin
bpln_RS20135 599710..600639 - 930 WP_055139794.1 spherulation-specific family 4 protein -
bpln_RS20140 601070..602269 + 1200 WP_055139795.1 acyl-CoA dehydrogenase family protein -
bpln_RS20145 602319..602822 - 504 WP_055139796.1 hypothetical protein -
bpln_RS20150 603100..603843 - 744 WP_042629249.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(157-408)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 48487.48 Da        Isoelectric Point: 7.8214

>T46166 WP_055139792.1 NZ_CP007213:c599227-597893 [Burkholderia plantarii]
MPRTSHATRLALWMNGIEVGYWERIQGVDRLAYAPGWLDHPQRRPLSLSLPFRPGNLPYQGAAVANYFDNLLPDSDAIRR
RLAQRHAARDTTPFALLEAVGRDCVGALQLLPEGQAPAGLKRIAGTPLDEAAIAQWLRALPLVAGTGRDSASHDLRLSIA
GAQEKTALLWHDGQWLRPEGSTPTTHILKLPLGLVAGLGADLRTSVENEWLCALLVAAYGLPVAPCGIGRFEDQKALVVE
RFDRRPSADGNWLVRLPQEDLCQATGTSGLNKYEADGGPGIDAVMDLLAGSIDAALDRRHFFTTQLVFWLLAAADGHGKN
FSIAHLPEARYRATPLYDVLSFHPILGRRAGQIAPQRLRMAMAVRGTHKHYGWQEIRTRHWIAQGRRCGLGEQTVRALIG
ELVAATPSVIDEVAALLPADFPGDLADAIFTGLRTQARQMETGL

Download         Length: 1335 bp

>T46166 NZ_CP007213:c599227-597893 [Burkholderia plantarii]
ATGCCACGCACCTCTCACGCCACGCGCCTCGCGCTCTGGATGAACGGCATCGAGGTCGGCTACTGGGAGCGGATCCAGGG
CGTCGATCGCCTCGCTTACGCACCGGGCTGGCTCGACCATCCGCAACGCCGCCCGCTGTCCCTGTCGCTGCCGTTCCGCC
CCGGCAATCTGCCTTATCAGGGCGCCGCCGTCGCGAATTACTTCGACAACCTGCTGCCCGACAGCGACGCGATTCGCCGC
CGCCTCGCGCAGCGTCACGCGGCGCGCGACACCACGCCGTTCGCGCTGCTCGAGGCGGTGGGGCGCGACTGCGTCGGTGC
CCTGCAACTGCTGCCGGAAGGCCAGGCGCCCGCCGGCCTGAAACGGATCGCCGGTACGCCGCTCGACGAGGCCGCGATCG
CGCAATGGCTGCGCGCGCTGCCGCTCGTCGCGGGCACCGGTCGCGACTCGGCCAGCCATGACCTGCGCCTGTCGATCGCC
GGCGCGCAGGAGAAAACCGCGCTGCTCTGGCACGACGGCCAATGGCTGCGCCCCGAAGGCAGCACGCCCACCACGCACAT
TCTCAAGCTGCCGCTCGGCCTCGTGGCCGGCCTCGGCGCCGACCTGCGCACCTCGGTCGAGAACGAATGGCTCTGCGCGC
TGCTGGTGGCCGCCTACGGGCTGCCCGTCGCGCCGTGCGGCATCGGCCGGTTCGAGGATCAAAAGGCGCTCGTGGTCGAA
CGTTTCGACCGGCGCCCCTCGGCCGACGGCAACTGGCTCGTGCGCCTGCCGCAGGAGGATTTGTGCCAGGCCACCGGCAC
GTCGGGCCTGAACAAATACGAAGCCGACGGCGGCCCCGGCATCGATGCGGTCATGGACCTCCTGGCCGGCTCGATCGACG
CGGCGCTCGACCGGCGCCACTTCTTCACGACACAACTGGTGTTCTGGCTGCTCGCGGCCGCCGACGGCCACGGCAAGAAT
TTCAGCATCGCGCATCTGCCCGAAGCACGTTATCGGGCCACGCCGCTCTACGATGTCCTGTCGTTTCATCCGATCCTGGG
GCGCCGCGCCGGACAGATCGCGCCGCAGCGCCTGCGCATGGCGATGGCCGTGCGCGGTACGCACAAGCATTACGGCTGGC
AGGAAATCCGCACGCGCCACTGGATCGCGCAGGGGCGCCGCTGCGGTTTGGGCGAGCAGACGGTGCGCGCGCTGATCGGC
GAACTCGTGGCCGCGACGCCGAGCGTGATCGACGAGGTCGCGGCGCTGCTGCCGGCCGATTTCCCCGGCGACCTCGCCGA
CGCGATCTTCACCGGCCTGCGCACGCAGGCCCGTCAAATGGAAACGGGCCTCTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 11960.55 Da        Isoelectric Point: 9.8258

>AT46166 WP_055139793.1 NZ_CP007213:c599574-599233 [Burkholderia plantarii]
VDYPVKTPAQLRPLLQGFRKAAGLTQAAMAERLGVTQQTYARLEADPTRASVERLFRVMRVLGIEMKLGGAAPEAAEPHA
GHAVPPSSSATATEPAAPTAGGRRGSDTPREDW

Download         Length: 342 bp

>AT46166 NZ_CP007213:c599574-599233 [Burkholderia plantarii]
GTGGACTATCCCGTCAAGACACCCGCCCAGTTGCGCCCCCTGCTGCAAGGTTTCCGCAAGGCGGCAGGGCTCACGCAGGC
CGCCATGGCCGAACGGCTCGGCGTCACGCAGCAGACCTACGCTCGCCTCGAAGCCGATCCGACCCGCGCGAGCGTCGAAC
GGCTGTTCCGCGTGATGCGCGTGCTCGGCATCGAAATGAAGCTGGGCGGCGCCGCGCCGGAAGCGGCCGAACCGCATGCC
GGCCATGCCGTCCCGCCGTCTTCATCGGCCACCGCCACCGAACCCGCCGCCCCCACTGCCGGCGGCCGGCGCGGCAGCGA
TACGCCCCGCGAGGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References