Detailed information of TA system TA046163

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 1563710..1564218
• Replicon: chromosome
• Accession: NZ_CP007208
• Organism: Staphylococcus xylosus strain HKUOPL8

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: BE24_RS07600
• Protein ID: WP_029377966.1
• Coordinates: 1563710..1563910 (-)
• Length: 67 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A418I4X8
• Locus tag: BE24_RS07605
• Protein ID: WP_029377967.1
• Coordinates: 1563925..1564218 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BE24_RS07585	1559179..1560534	-	1356	WP_038678886.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
BE24_RS07590	1560547..1561617	-	1071	WP_038678888.1	D-alanine--D-alanine ligase	-
BE24_RS07595	1561869..1563074	+	1206	WP_038678890.1	rod shape-determining protein RodA	-
BE24_RS13750	1563354..1563494	-	141	WP_099265859.1	hypothetical protein	-
BE24_RS07600	1563710..1563910	-	201	WP_029377966.1	heavy-metal-associated domain-containing protein	Toxin
BE24_RS07605	1563925..1564218	-	294	WP_029377967.1	copper-sensing transcriptional repressor CsoR	Antitoxin
BE24_RS07610	1564361..1565845	+	1485	WP_029377968.1	cardiolipin synthase	-
BE24_RS07615	1565958..1566605	+	648	WP_029377969.1	HD domain-containing protein	-
BE24_RS07620	1566703..1567590	-	888	WP_038678892.1	membrane protein insertase YidC	-
BE24_RS07625	1567678..1568316	-	639	WP_037557147.1	thiamine phosphate synthase	-
BE24_RS07630	1568319..1569107	-	789	WP_038678895.1	hydroxyethylthiazole kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (19-64)

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 67 a.a.
• Molecular weight: 7628.68 Da
• Isoelectric Point: 4.3997

>T46163 WP_029377966.1 NZ_CP007208:c1563910-1563710 [Staphylococcus xylosus]
VQSKVIYVSDINSERQYQIKQRLMNVIGVHNVAIDIDKGEILVDFETPASLNNLEKEIYDLGYQIF

Nucleotide

• Length: 201 bp

>T46163 NZ_CP007208:c1563910-1563710 [Staphylococcus xylosus]
GTGCAATCAAAAGTAATTTACGTCTCAGATATTAATTCAGAACGACAATATCAAATAAAACAACGATTAATGAATGTTAT
AGGTGTACACAATGTTGCTATAGATATTGACAAAGGAGAAATACTTGTCGATTTTGAAACACCTGCGAGTTTAAATAATT
TGGAAAAAGAAATTTATGATCTTGGATATCAAATATTTTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11195.85 Da
• Isoelectric Point: 6.8624

>AT46163 WP_029377967.1 NZ_CP007208:c1564218-1563925 [Staphylococcus xylosus]
VTEIQKAHHSDQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEKGQQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT46163 NZ_CP007208:c1564218-1563925 [Staphylococcus xylosus]
GTGACAGAAATACAAAAAGCGCATCATTCAGACCAAATAAAATCAAATTTGAAATCAAGACTAAATAGAATAGAAGGGCA
AGTGCGAGCAATAAACCGTATGGTAGATGAAGATGTTTATTGTGACGATGTACTTACTCAAATTAGAGCGACACGTTCTG
CACTAAATAGCGTAGCAACTAAATTGTTGGATCATCATATGAAAAGTTGCATCATGGATAAAGTGGAAAAAGGTCAACAA
GAAGAAGCAATGGAAGAATTATTAGTAACTTTTCAAAAATTAATGAAGGATTAG

Structures

Antitoxin

• AlphaFold DB: A0A418I4X8