Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2736060..2736651 Replicon chromosome
Accession NZ_CP007201
Organism Sulfurospirillum multivorans DSM 12446

Toxin (Protein)


Gene name hicA Uniprot ID A0A5B9TV06
Locus tag SMUL_RS14165 Protein ID WP_025345913.1
Coordinates 2736060..2736314 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5B9TVU5
Locus tag SMUL_RS14170 Protein ID WP_025345914.1
Coordinates 2736307..2736651 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMUL_RS14145 2731536..2732224 - 689 Protein_2808 response regulator transcription factor -
SMUL_RS14150 2732346..2733974 - 1629 WP_025345910.1 methyl-accepting chemotaxis protein -
SMUL_RS14155 2734178..2734402 + 225 WP_025345911.1 hypothetical protein -
SMUL_RS14160 2734506..2735930 + 1425 WP_025345912.1 hypothetical protein -
SMUL_RS14165 2736060..2736314 + 255 WP_025345913.1 type II toxin-antitoxin system HicA family toxin Toxin
SMUL_RS14170 2736307..2736651 + 345 WP_025345914.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SMUL_RS14175 2736712..2738013 - 1302 WP_025345915.1 DNA polymerase IV -
SMUL_RS14180 2738342..2738914 + 573 WP_025345916.1 DedA family protein -
SMUL_RS14185 2738911..2739261 - 351 WP_025345917.1 hypothetical protein -
SMUL_RS14190 2739401..2741386 - 1986 WP_025345918.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(22-81)

Antitoxin

Uncharacterised protein family HicB

(55-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9683.46 Da        Isoelectric Point: 10.3565

>T46159 WP_025345913.1 NZ_CP007201:2736060-2736314 [Sulfurospirillum multivorans DSM 12446]
MSKKDKLWAKFMEVPPKKNLTWNELSALMLALGFEALQGDGSRVKFYHKAKDIMINLHKPHPGNLLKTYLVKQIQDKLKE
AFDG

Download         Length: 255 bp

>T46159 NZ_CP007201:2736060-2736314 [Sulfurospirillum multivorans DSM 12446]
ATGAGTAAAAAAGATAAACTTTGGGCTAAATTTATGGAAGTCCCACCCAAAAAGAACTTAACTTGGAATGAACTCTCCGC
ATTGATGTTAGCGCTTGGTTTTGAAGCATTACAGGGTGATGGCTCACGAGTGAAGTTTTATCATAAAGCTAAAGACATAA
TGATCAATCTTCATAAACCCCATCCTGGCAATTTACTCAAAACGTATCTTGTAAAACAGATACAAGACAAACTAAAGGAG
GCATTTGATGGCTAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12936.69 Da        Isoelectric Point: 4.6967

>AT46159 WP_025345914.1 NZ_CP007201:2736307-2736651 [Sulfurospirillum multivorans DSM 12446]
MANVLTYQNYTGSVEYSHEDRCFFGKIEFINDLITFEATSVDELETNFQEAVESYMLTCKELGKEPQKQFNGVFNIRPGV
ELHMAAARKAMEVGMSLNAYIKSLIAKDTHLSIN

Download         Length: 345 bp

>AT46159 NZ_CP007201:2736307-2736651 [Sulfurospirillum multivorans DSM 12446]
ATGGCTAATGTATTGACCTATCAAAACTATACTGGCTCAGTAGAATACAGTCATGAAGACCGATGTTTCTTTGGAAAAAT
CGAATTTATTAATGACTTGATCACCTTTGAAGCGACGAGTGTTGATGAGCTCGAAACCAATTTTCAAGAAGCGGTTGAGA
GTTATATGCTTACATGTAAAGAGCTAGGCAAAGAGCCACAAAAGCAATTTAACGGCGTGTTCAACATTCGCCCAGGCGTT
GAACTGCATATGGCGGCTGCGCGTAAAGCGATGGAAGTGGGGATGTCTTTGAACGCTTATATCAAAAGTCTTATCGCTAA
AGATACCCATCTTTCTATCAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B9TV06

Antitoxin

Source ID Structure
AlphaFold DB A0A5B9TVU5

References