Detailed information of TA system TA046158

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 1284795..1285432
• Replicon: chromosome
• Accession: NZ_CP007201
• Organism: Sulfurospirillum multivorans DSM 12446

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SMUL_RS06580
• Protein ID: WP_025344463.1
• Coordinates: 1285031..1285432 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A5B9TR85
• Locus tag: SMUL_RS06575
• Protein ID: WP_025344462.1
• Coordinates: 1284795..1285034 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMUL_RS06555	1280519..1281643	-	1125	WP_025344458.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
SMUL_RS06560	1281658..1282695	+	1038	WP_148295274.1	HlyD family efflux transporter periplasmic adaptor subunit	-
SMUL_RS06565	1282692..1283630	+	939	WP_025344460.1	ABC transporter ATP-binding protein	-
SMUL_RS06570	1283627..1284730	+	1104	WP_025344461.1	ABC transporter permease	-
SMUL_RS06575	1284795..1285034	+	240	WP_025344462.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SMUL_RS06580	1285031..1285432	+	402	WP_025344463.1	type II toxin-antitoxin system VapC family toxin	Toxin
SMUL_RS06585	1285535..1286566	+	1032	WP_025344464.1	hypothetical protein	-
SMUL_RS06590	1286575..1287297	-	723	WP_158506022.1	hypothetical protein	-
SMUL_RS17230	1287306..1287452	-	147	WP_169730520.1	hypothetical protein	-
SMUL_RS06595	1287617..1287877	-	261	WP_025344466.1	helix-turn-helix domain-containing protein	-
SMUL_RS06600	1288024..1289157	+	1134	WP_025344467.1	aldo/keto reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (8-52)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15116.71 Da
• Isoelectric Point: 7.2419

>T46158 WP_025344463.1 NZ_CP007201:1285031-1285432 [Sulfurospirillum multivorans DSM 12446]
MKKMLDTNICIYIIKNKPQSVLDELKKCNVGDIILSSITVSELIYGAHKSQFVEKNLKAIEHFLIPFDVAEYDYKAALEY
GKLRASLEKKGQPIGSLDMLIAAHAKSLDMVLVTNNMKEFERVEGLNVENWVR

Nucleotide

• Length: 402 bp

>T46158 NZ_CP007201:1285031-1285432 [Sulfurospirillum multivorans DSM 12446]
TTGAAAAAAATGCTCGATACCAACATCTGTATCTATATCATTAAAAACAAACCTCAAAGTGTCTTAGACGAGCTCAAAAA
ATGCAATGTAGGCGACATCATCCTCTCTTCTATCACGGTTTCTGAGTTGATTTATGGAGCGCATAAAAGTCAATTTGTCG
AAAAAAACCTCAAAGCCATTGAACATTTCCTCATCCCTTTTGATGTCGCTGAGTATGATTATAAAGCAGCTTTGGAGTAT
GGAAAACTAAGGGCAAGTTTAGAAAAAAAAGGACAACCCATCGGTTCTTTAGATATGCTCATCGCCGCCCATGCAAAATC
ACTTGATATGGTGCTCGTGACCAATAATATGAAAGAGTTTGAGAGGGTTGAGGGGTTGAATGTTGAGAATTGGGTGCGTT
GA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9377.66 Da
• Isoelectric Point: 7.0128

>AT46158 WP_025344462.1 NZ_CP007201:1284795-1285034 [Sulfurospirillum multivorans DSM 12446]
MTSTAKLFQNGQSQAIRLPKEYRFEHQQEVIIKKIDGAILIFPKNDKSVWEKMFDTLGNFSDDFLAQRRQPTQEREELF

Nucleotide

• Length: 240 bp

>AT46158 NZ_CP007201:1284795-1285034 [Sulfurospirillum multivorans DSM 12446]
ATGACTTCTACAGCAAAACTATTTCAAAATGGTCAAAGTCAAGCTATACGCCTTCCCAAGGAGTATCGGTTTGAACATCA
ACAAGAGGTTATCATCAAAAAAATAGATGGTGCCATTTTGATATTCCCTAAAAACGATAAAAGTGTTTGGGAAAAAATGT
TCGATACTCTGGGTAACTTTTCAGATGACTTTCTAGCGCAAAGAAGACAACCAACACAAGAGCGAGAGGAGCTGTTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A5B9TR85