Detailed information of TA system TA046157

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 1163301..1163938
• Replicon: chromosome
• Accession: NZ_CP007201
• Organism: Sulfurospirillum multivorans DSM 12446

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SMUL_RS05930
• Protein ID: WP_025344340.1
• Coordinates: 1163537..1163938 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A5B9TQW3
• Locus tag: SMUL_RS05925
• Protein ID: WP_025344339.1
• Coordinates: 1163301..1163540 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMUL_RS05905	1158934..1160511	-	1578	WP_025344335.1	cbb3-type cytochrome c oxidase subunit I	-
SMUL_RS05910	1160495..1161118	-	624	WP_025344336.1	ABC transporter ATP-binding protein	-
SMUL_RS05915	1161118..1162200	-	1083	WP_025344337.1	FtsX-like permease family protein	-
SMUL_RS05920	1162338..1163222	+	885	WP_025344338.1	3'-5' exonuclease	-
SMUL_RS05925	1163301..1163540	+	240	WP_025344339.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SMUL_RS05930	1163537..1163938	+	402	WP_025344340.1	type II toxin-antitoxin system VapC family toxin	Toxin
SMUL_RS05935	1164031..1164393	+	363	WP_025344341.1	hypothetical protein	-
SMUL_RS05940	1164466..1165812	+	1347	WP_084613089.1	AAA family ATPase	-
SMUL_RS05945	1165809..1166579	+	771	WP_025344343.1	TIGR02646 family protein	-
SMUL_RS05950	1166624..1167826	-	1203	WP_025344344.1	IS256 family transposase	-
SMUL_RS05955	1168027..1168467	-	441	WP_025344345.1	isoprenylcysteine carboxylmethyltransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (8-54)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15068.58 Da
• Isoelectric Point: 6.7146

>T46157 WP_025344340.1 NZ_CP007201:1163537-1163938 [Sulfurospirillum multivorans DSM 12446]
MKKMLDTNICIYIIKNKPPSVLEELKKCDVGDIILSSITVSELIYGAHKSQFVEKTLKAIEHFLIPFDVADYDYKASLEY
GKIRANLEQKGQPIGSLDTLIAAHAKSLDVVLVTNNMKEFERVEGLKVENWVR

Nucleotide

• Length: 402 bp

>T46157 NZ_CP007201:1163537-1163938 [Sulfurospirillum multivorans DSM 12446]
TTGAAAAAAATGCTCGACACAAACATCTGCATCTATATCATTAAAAACAAACCACCAAGTGTTTTAGAAGAGCTCAAAAA
ATGCGATGTAGGCGACATTATCCTCTCTTCCATTACTGTGTCTGAGTTGATTTACGGAGCACATAAAAGTCAATTTGTCG
AAAAAACCCTCAAAGCCATTGAGCATTTCCTCATTCCTTTTGATGTCGCTGATTACGATTACAAAGCATCGTTAGAATAC
GGGAAAATACGTGCAAATTTGGAGCAAAAAGGACAACCCATCGGCTCTTTAGACACACTCATCGCCGCACATGCGAAGTC
ACTTGATGTTGTGCTCGTGACCAATAATATGAAAGAGTTTGAGAGGGTTGAGGGTTTGAAAGTTGAGAATTGGGTGAGGT
GA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9318.64 Da
• Isoelectric Point: 5.8317

>AT46157 WP_025344339.1 NZ_CP007201:1163301-1163540 [Sulfurospirillum multivorans DSM 12446]
MTSTAKLFQNGQSQAIRLPKEFRFEHQQEVIIKKIDGAILIFPKNDKSVWEKMFETLGNFSDDFLAQRVQPTQEREELF

Nucleotide

• Length: 240 bp

>AT46157 NZ_CP007201:1163301-1163540 [Sulfurospirillum multivorans DSM 12446]
ATGACTTCCACAGCAAAATTATTTCAAAACGGTCAAAGCCAAGCCATACGCCTTCCCAAAGAGTTTCGGTTTGAGCATCA
ACAAGAAGTTATCATCAAAAAAATCGATGGTGCCATTTTGATTTTCCCAAAAAATGATAAAAGCGTTTGGGAAAAAATGT
TTGAAACACTGGGTAACTTTTCAGATGATTTTCTAGCTCAAAGGGTTCAGCCAACGCAAGAGCGAGAGGAGCTGTTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A5B9TQW3