Detailed information of TA system TA046155

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 609246..609751
• Replicon: chromosome
• Accession: NZ_CP007201
• Organism: Sulfurospirillum multivorans DSM 12446

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A1D7THD5
• Locus tag: SMUL_RS03175
• Protein ID: WP_025343819.1
• Coordinates: 609491..609751 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1D7THA9
• Locus tag: SMUL_RS03170
• Protein ID: WP_025343818.1
• Coordinates: 609246..609494 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMUL_RS03125	605008..605301	+	294	WP_025343809.1	nucleotidyltransferase	-
SMUL_RS03130	605294..605647	+	354	WP_025343810.1	DUF86 domain-containing protein	-
SMUL_RS03135	605790..607118	+	1329	WP_025343811.1	OprD family outer membrane porin	-
SMUL_RS03140	607281..607562	+	282	WP_025343812.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
SMUL_RS03145	607549..607872	+	324	WP_025343813.1	type II toxin-antitoxin system RelE/ParE family toxin	-
SMUL_RS03150	607985..608239	+	255	WP_084613067.1	DUF4258 domain-containing protein	-
SMUL_RS03155	608229..608426	+	198	WP_025343815.1	DUF2283 domain-containing protein	-
SMUL_RS03160	608662..608877	+	216	WP_025343816.1	CopG family transcriptional regulator	-
SMUL_RS03165	608867..609121	+	255	WP_025343817.1	type II toxin-antitoxin system RelE/ParE family toxin	-
SMUL_RS03170	609246..609494	+	249	WP_025343818.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
SMUL_RS03175	609491..609751	+	261	WP_025343819.1	Txe/YoeB family addiction module toxin	Toxin
SMUL_RS03180	609877..611163	+	1287	WP_025343820.1	OprD family outer membrane porin	-
SMUL_RS03185	611322..611612	+	291	WP_025343821.1	nucleotidyltransferase domain-containing protein	-
SMUL_RS03190	611830..612084	+	255	WP_145923217.1	hypothetical protein	-
SMUL_RS03195	612380..613498	+	1119	WP_025343823.1	ABC transporter substrate-binding protein	-
SMUL_RS03200	613611..614495	+	885	WP_038533775.1	branched-chain amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10353.99 Da
• Isoelectric Point: 9.3793

>T46155 WP_025343819.1 NZ_CP007201:609491-609751 [Sulfurospirillum multivorans DSM 12446]
MIIGFAAKGWEDYLYWQENDKKIVKRINLLLEDIKRNPHDSNGIGKPERLKGDLEKYFSRRITAEHRLVYKFLDDLIIVA
QCRFHY

Nucleotide

• Length: 261 bp

>T46155 NZ_CP007201:609491-609751 [Sulfurospirillum multivorans DSM 12446]
ATGATCATTGGCTTTGCCGCGAAAGGATGGGAAGATTATCTTTATTGGCAAGAAAATGATAAAAAAATTGTAAAACGCAT
CAATCTACTTTTAGAAGATATTAAACGAAATCCACATGATAGCAATGGTATTGGAAAACCAGAACGACTAAAAGGTGACT
TGGAAAAATACTTTTCAAGGCGTATTACTGCAGAGCATCGATTGGTTTATAAATTTTTGGATGATTTAATTATTGTGGCA
CAATGCAGATTTCATTATTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9486.84 Da
• Isoelectric Point: 4.7246

>AT46155 WP_025343818.1 NZ_CP007201:609246-609494 [Sulfurospirillum multivorans DSM 12446]
MQAIFYSQARNNLRSIISKACTDFDQFIITTKDNQSVVLMSYDEYSAIKETMYLLSSKTNRDRLLDAVEEIEGMKFTCKE
IA

Nucleotide

• Length: 249 bp

>AT46155 NZ_CP007201:609246-609494 [Sulfurospirillum multivorans DSM 12446]
ATGCAAGCCATTTTTTATTCACAGGCTAGAAATAACCTAAGAAGTATTATAAGCAAAGCATGCACGGATTTTGATCAGTT
CATCATTACAACAAAAGATAATCAGTCTGTTGTGCTCATGTCCTACGATGAATACAGTGCCATCAAAGAAACAATGTACC
TACTTTCTTCAAAAACTAATAGAGATAGGCTCTTAGATGCTGTTGAAGAGATTGAAGGTATGAAATTTACATGTAAAGAA
ATTGCATGA

Structures

Toxin

• AlphaFold DB: A0A1D7THD5

Antitoxin

• AlphaFold DB: A0A1D7THA9