Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 520857..521388 Replicon chromosome
Accession NZ_CP007201
Organism Sulfurospirillum multivorans DSM 12446

Toxin (Protein)


Gene name relE Uniprot ID A0A5B9TP09
Locus tag SMUL_RS02715 Protein ID WP_025343727.1
Coordinates 521098..521388 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5B9TP06
Locus tag SMUL_RS02710 Protein ID WP_025343726.1
Coordinates 520857..521108 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMUL_RS02695 516402..516995 + 594 WP_025343723.1 ORF6N domain-containing protein -
SMUL_RS02700 517110..518045 + 936 WP_025343724.1 SIR2 family protein -
SMUL_RS02705 518042..520768 + 2727 WP_025343725.1 hypothetical protein -
SMUL_RS02710 520857..521108 + 252 WP_025343726.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SMUL_RS02715 521098..521388 + 291 WP_025343727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SMUL_RS16475 521500..524337 + 2838 WP_025343728.1 transporter substrate-binding domain-containing protein -
SMUL_RS02725 524355..525533 - 1179 WP_025343729.1 sugar transporter -
SMUL_RS02730 525671..526072 + 402 WP_025343730.1 SEC-C domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11356.34 Da        Isoelectric Point: 10.3319

>T46153 WP_025343727.1 NZ_CP007201:521098-521388 [Sulfurospirillum multivorans DSM 12446]
MSYELEFHPQALKEWKNLGETIKEQFKKKLKERLENPKVPKDKLVGFDAVYKIKLKAFGYRLAYEVIDERVVVMVLAVGK
RENNRVYNALHSRFGK

Download         Length: 291 bp

>T46153 NZ_CP007201:521098-521388 [Sulfurospirillum multivorans DSM 12446]
ATGAGCTATGAGTTAGAATTTCACCCACAAGCGCTTAAAGAGTGGAAGAATTTGGGTGAGACGATTAAAGAGCAGTTCAA
AAAGAAACTGAAAGAGAGACTTGAAAATCCGAAAGTTCCCAAAGACAAACTGGTTGGATTTGATGCCGTCTATAAAATAA
AACTCAAAGCATTTGGCTATCGACTTGCGTATGAAGTGATTGATGAGAGAGTTGTTGTTATGGTATTGGCGGTTGGAAAA
AGAGAAAACAACAGAGTGTATAATGCCCTTCATTCTCGATTTGGCAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9309.64 Da        Isoelectric Point: 4.3455

>AT46153 WP_025343726.1 NZ_CP007201:520857-521108 [Sulfurospirillum multivorans DSM 12446]
MQPILSNYTASITELKKSPTQILENAGDEVVAILNHNVASAYLVPSKTYEKLMAMLDDYMLSKEVTSRQSEDYTPIKVTL
DEL

Download         Length: 252 bp

>AT46153 NZ_CP007201:520857-521108 [Sulfurospirillum multivorans DSM 12446]
ATGCAACCTATTTTATCCAACTATACAGCAAGTATCACAGAACTTAAAAAATCACCGACGCAAATTCTTGAAAATGCAGG
GGATGAGGTTGTTGCCATACTCAATCACAATGTGGCGAGTGCTTACCTTGTTCCTTCTAAAACCTATGAAAAGCTAATGG
CGATGTTGGATGATTATATGCTCTCCAAAGAAGTCACAAGCAGGCAAAGTGAAGATTATACGCCCATCAAAGTAACGCTT
GATGAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B9TP09

Antitoxin

Source ID Structure
AlphaFold DB A0A5B9TP06

References