Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) virAT/YafQ(toxin)
Location 23873..24429 Replicon plasmid pRM1875_35kb
Accession NZ_CP007184
Organism Campylobacter coli RM1875

Toxin (Protein)


Gene name virT Uniprot ID A0A381CEC5
Locus tag YSQ_RS09715 Protein ID WP_002815875.1
Coordinates 23873..24142 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name virA Uniprot ID A0A381CEB0
Locus tag YSQ_RS09720 Protein ID WP_002815874.1
Coordinates 24142..24429 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YSQ_RS09695 20334..20576 - 243 WP_025443369.1 hypothetical protein -
YSQ_RS09700 20576..20884 - 309 WP_025443370.1 hypothetical protein -
YSQ_RS09705 21569..23140 + 1572 WP_025443371.1 relaxase/mobilization nuclease domain-containing protein -
YSQ_RS09710 23367..23759 - 393 WP_002814547.1 hypothetical protein -
YSQ_RS09715 23873..24142 - 270 WP_002815875.1 type II toxin-antitoxin system YafQ family toxin Toxin
YSQ_RS09720 24142..24429 - 288 WP_002815874.1 hypothetical protein Antitoxin
YSQ_RS09725 24653..25015 - 363 WP_025443372.1 hypothetical protein -
YSQ_RS09730 25216..25581 - 366 WP_002815629.1 hypothetical protein -
YSQ_RS09735 25770..26072 - 303 WP_025443373.1 hypothetical protein -
YSQ_RS09740 26072..26503 - 432 WP_025443374.1 hypothetical protein -
YSQ_RS09745 26500..26916 - 417 WP_025443375.1 hypothetical protein -
YSQ_RS09755 27452..27670 - 219 WP_025443376.1 hypothetical protein -
YSQ_RS09760 27682..27987 - 306 WP_025443377.1 hypothetical protein -
YSQ_RS09765 28001..28345 - 345 WP_011117579.1 hypothetical protein -
YSQ_RS09770 28806..29234 - 429 WP_025443378.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - virD4 / virB11 / virB10 / virB9 / virB8 / Cjp54 / virB4 1..35364 35364


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10604.23 Da        Isoelectric Point: 8.7651

>T46152 WP_002815875.1 NZ_CP007184:c24142-23873 [Campylobacter coli RM1875]
MKYNIAYSPKFKKAYKKLNAKEELETDIIINRLANDETLEEKYKDHALKGNYIGFRECHIKPDLLLVYRKRDDILELYLA
NLGNHNNIF

Download         Length: 270 bp

>T46152 NZ_CP007184:c24142-23873 [Campylobacter coli RM1875]
ATGAAATATAATATCGCATATTCTCCGAAATTTAAAAAAGCATATAAAAAATTAAATGCAAAAGAAGAGTTAGAAACCGA
TATAATTATTAACAGACTTGCTAATGATGAAACACTAGAAGAAAAATACAAAGACCACGCATTAAAAGGAAATTATATTG
GTTTTAGAGAATGCCATATAAAACCTGATTTGCTTTTAGTCTATCGCAAAAGAGATGATATTTTAGAATTGTATTTGGCT
AATTTGGGAAATCACAACAATATTTTTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11248.82 Da        Isoelectric Point: 8.8584

>AT46152 WP_002815874.1 NZ_CP007184:c24429-24142 [Campylobacter coli RM1875]
MFDYSKYENASEKQLIHALTLAEKRAEKLNSQLKENNEFFKFLQKKLKKSFNAKKTKKAEQRRPELDEAIEDYKNGNVVV
CHSMEEFKAKMAEED

Download         Length: 288 bp

>AT46152 NZ_CP007184:c24429-24142 [Campylobacter coli RM1875]
ATGTTTGATTATTCTAAATATGAAAATGCTAGCGAAAAACAATTAATACACGCTTTGACTTTAGCAGAAAAAAGGGCGGA
GAAACTAAACTCGCAATTAAAAGAGAATAACGAATTTTTTAAATTTTTACAAAAAAAGTTAAAAAAATCTTTTAACGCCA
AAAAAACAAAAAAAGCAGAGCAAAGAAGACCTGAATTAGATGAAGCGATTGAAGATTATAAAAATGGAAATGTGGTAGTT
TGTCATAGTATGGAAGAATTTAAGGCAAAAATGGCAGAAGAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A381CEC5

Antitoxin

Source ID Structure
AlphaFold DB A0A381CEB0

References