Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 889195..889672 Replicon chromosome
Accession NZ_CP007176
Organism Staphylococcus aureus USA300-ISMMS1

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag AZ30_RS04335 Protein ID WP_000052078.1
Coordinates 889195..889383 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AZ30_RS04340 Protein ID WP_001059690.1
Coordinates 889412..889672 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AZ30_RS04305 885235..885705 + 471 WP_000824472.1 hypothetical protein -
AZ30_RS04310 886046..886732 + 687 WP_001548082.1 thermonuclease family protein -
AZ30_RS04315 887089..887289 + 201 WP_001059082.1 cold-shock protein -
AZ30_RS04320 887786..888004 - 219 WP_000005886.1 hypothetical protein -
AZ30_RS04325 888066..888350 - 285 WP_001004395.1 hypothetical protein -
AZ30_RS04330 888438..889007 - 570 WP_001106654.1 hypothetical protein -
AZ30_RS04335 889195..889383 - 189 WP_000052078.1 hypothetical protein Toxin
AZ30_RS04340 889412..889672 - 261 WP_001059690.1 hypothetical protein Antitoxin
AZ30_RS04345 890013..890216 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AZ30_RS04350 890213..890449 - 237 WP_000368687.1 hypothetical protein -
AZ30_RS04355 890674..891255 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
AZ30_RS04360 891328..891945 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
AZ30_RS04365 892100..892594 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
AZ30_RS04370 892993..893415 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
AZ30_RS04375 893563..894279 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 883878..914961 31083


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T46134 WP_000052078.1 NZ_CP007176:c889383-889195 [Staphylococcus aureus USA300-ISMMS1]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T46134 NZ_CP007176:c889383-889195 [Staphylococcus aureus USA300-ISMMS1]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT46134 WP_001059690.1 NZ_CP007176:c889672-889412 [Staphylococcus aureus USA300-ISMMS1]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT46134 NZ_CP007176:c889672-889412 [Staphylococcus aureus USA300-ISMMS1]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References