46131

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 937500..938129 Replicon chromosome
Accession NZ_CP007172
Organism Listeria ivanovii WSLC3009

Toxin (Protein)


Gene name pemK Uniprot ID A0A097BBV7
Locus tag AX25_RS19575 Protein ID WP_025279828.1
Coordinates 937782..938129 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G2ZDP2
Locus tag AX25_RS19570 Protein ID WP_014092317.1
Coordinates 937500..937778 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AX25_RS19550 932840..934312 + 1473 WP_014092313.1 PH domain-containing protein -
AX25_RS19555 934433..935812 + 1380 WP_014092314.1 protoporphyrinogen oxidase -
AX25_RS19560 935814..936170 + 357 WP_014092315.1 holo-ACP synthase -
AX25_RS19565 936188..937294 + 1107 WP_014092316.1 alanine racemase -
AX25_RS19570 937500..937778 + 279 WP_014092317.1 CopG family ribbon-helix-helix protein Antitoxin
AX25_RS19575 937782..938129 + 348 WP_025279828.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AX25_RS19580 938379..939215 + 837 WP_014092318.1 STAS domain-containing protein -
AX25_RS19585 939221..939577 + 357 WP_003721457.1 STAS domain-containing protein -
AX25_RS19590 939580..939990 + 411 WP_014092320.1 anti-sigma regulatory factor -
AX25_RS19595 940007..941011 + 1005 WP_025279829.1 PP2C family protein-serine/threonine phosphatase -
AX25_RS19600 941163..941507 + 345 WP_014092322.1 anti sigma b factor antagonist RsbV -
AX25_RS19605 941491..941964 + 474 WP_014092323.1 anti-sigma B factor RsbW -
AX25_RS19610 941942..942721 + 780 WP_014092324.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12829.90 Da        Isoelectric Point: 6.4735

>T46131 WP_025279828.1 NZ_CP007172:937782-938129 [Listeria ivanovii WSLC3009]
MMVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIR
TIDKQRLTDKITHLDEELMVKVNQALEVSLGVVEF

Download         Length: 348 bp

>T46131 NZ_CP007172:937782-938129 [Listeria ivanovii WSLC3009]
CTGATGGTGAAGCGTGGTGACGTATACTACGCGGACCTTTCCCCCGTGGTCGGAAGCGAGCAAGGGGGAATACGGCCTGT
TCTCATCATTCAAAACGACATTGGTAATAGATTCAGCCCAACTGTGATTGTGGCAGCAATAACCGCAAAGATTCAAAAAG
CAAAGCTGCCAACACATGTGGAAGCTACTCGTAAAGATGGCTTTGAAAGAGATTCTGTCATTCTTTTAGAACAAATTAGA
ACAATTGACAAACAACGCCTGACAGATAAGATTACACATTTGGACGAGGAACTAATGGTCAAGGTAAACCAGGCGCTGGA
AGTCAGTCTAGGAGTAGTAGAATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10621.13 Da        Isoelectric Point: 4.2980

>AT46131 WP_014092317.1 NZ_CP007172:937500-937778 [Listeria ivanovii WSLC3009]
VLEKEKRMIISVELTQEMVQELDVVVEKEKMGRSEVIMEATQQFLQEKRARELRDEMERGYAEMATINFAIACECTHVES
EAEDRNISILGG

Download         Length: 279 bp

>AT46131 NZ_CP007172:937500-937778 [Listeria ivanovii WSLC3009]
GTGTTAGAGAAAGAAAAGCGGATGATAATATCCGTAGAACTGACACAAGAAATGGTACAGGAACTCGACGTAGTTGTAGA
AAAAGAAAAAATGGGGCGGAGTGAAGTTATAATGGAAGCAACGCAACAATTTTTGCAAGAGAAAAGGGCACGTGAGTTGA
GAGACGAGATGGAGCGCGGCTATGCGGAAATGGCGACAATTAACTTTGCTATCGCATGCGAGTGTACCCATGTCGAATCA
GAAGCAGAAGACAGAAATATTAGTATTTTAGGAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097BBV7

Antitoxin

Source ID Structure
AlphaFold DB G2ZDP2

References