Detailed information of TA system TA046122

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PHD(antitoxin)
• Location: 7574546..7575240
• Replicon: chromosome
• Accession: NZ_CP007155
• Organism: Kutzneria albida DSM 43870

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KALB_RS32720
• Protein ID: WP_051912949.1
• Coordinates: 7574546..7574947 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: W5WHD3
• Locus tag: KALB_RS32725
• Protein ID: WP_025359893.1
• Coordinates: 7574944..7575240 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KALB_RS32705	7572349..7572804	-	456	WP_025359889.1	transcriptional regulator NrdR	-
KALB_RS48870	7573040..7573315	-	276	WP_035967923.1	LysM peptidoglycan-binding domain-containing protein	-
KALB_RS32715	7573778..7574482	+	705	WP_030108290.1	transcriptional repressor LexA	-
KALB_RS32720	7574546..7574947	-	402	WP_051912949.1	type II toxin-antitoxin system VapC family toxin	Toxin
KALB_RS32725	7574944..7575240	-	297	WP_025359893.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KALB_RS32730	7575345..7575635	-	291	WP_025359894.1	Sec-independent protein translocase subunit TatA	-
KALB_RS32735	7575704..7577146	-	1443	WP_025359895.1	GTPase HflX	-
KALB_RS32740	7577200..7577658	-	459	WP_201772067.1	transcriptional regulator	-
KALB_RS32745	7577764..7579017	+	1254	WP_025359897.1	MFS transporter	-
KALB_RS32750	7579142..7579639	-	498	WP_025359898.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-120)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14431.26 Da
• Isoelectric Point: 4.1684

>T46122 WP_051912949.1 NZ_CP007155:c7574947-7574546 [Kutzneria albida DSM 43870]
VSLYYVDTSAALKLLAEESHSKAFAAFYDSQTSASWVSSSLLRVEVMRAVSRVLPAAIPDARDLLLAFDYISMDDDVVDG
AMNEPDRMLRSLDAIHLSTARLLGTDLDAVVTYDDRLATAATDAGFTVLAPRD

Nucleotide

• Length: 402 bp

>T46122 NZ_CP007155:c7574947-7574546 [Kutzneria albida DSM 43870]
GTGAGCCTGTACTACGTCGACACCTCGGCCGCCCTCAAGCTGCTGGCCGAGGAGAGCCATTCCAAGGCGTTCGCCGCGTT
CTACGACAGCCAGACCAGCGCGTCCTGGGTCAGTTCCTCGCTGCTGCGCGTCGAGGTGATGCGCGCCGTCTCCCGCGTGT
TGCCCGCGGCGATTCCGGACGCGCGTGACCTCCTGCTCGCGTTCGACTACATCAGCATGGACGACGACGTGGTCGACGGC
GCCATGAACGAGCCGGATCGAATGCTGCGCTCGCTGGACGCCATCCACCTCTCGACGGCTCGACTCCTCGGCACCGACCT
GGACGCCGTGGTCACCTACGACGACCGGTTGGCCACTGCCGCCACCGACGCCGGATTCACGGTCCTCGCACCTCGCGACT
GA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11343.93 Da
• Isoelectric Point: 10.6420

>AT46122 WP_025359893.1 NZ_CP007155:c7575240-7574944 [Kutzneria albida DSM 43870]
MERREDYTVGLRELRHNTSEVLARVRRGVTVDVTEYGRLIARIVPVEDRAPTPAMTRLVESGKARLATRPGYRPRMRPSV
GQDRLGEALRELREEDTW

Nucleotide

• Length: 297 bp

>AT46122 NZ_CP007155:c7575240-7574944 [Kutzneria albida DSM 43870]
ATGGAGCGCCGCGAGGACTACACCGTTGGCCTGCGGGAACTGCGCCACAACACCAGTGAGGTGTTGGCCAGGGTCCGGCG
CGGCGTGACGGTCGATGTCACCGAGTACGGTCGCCTGATCGCACGGATCGTGCCGGTCGAGGATCGCGCGCCGACCCCGG
CGATGACGCGGCTGGTGGAGTCGGGCAAGGCGAGGCTGGCGACCCGGCCCGGATACCGGCCGCGGATGCGTCCCAGCGTC
GGTCAGGACCGTCTTGGCGAAGCGCTCCGGGAGCTGCGCGAGGAAGACACCTGGTGA

Structures

Antitoxin

• AlphaFold DB: W5WHD3