Detailed information of TA system TA046121

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 523910..525066
• Replicon: chromosome
• Accession: NZ_CP007151
• Organism: Marinobacter similis strain A3d10

Toxin (Protein)

• Gene name: -
• Uniprot ID: W5YN87
• Locus tag: AU14_RS02375
• Protein ID: WP_052471940.1
• Coordinates: 524272..525066 (+)
• Length: 265 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: W5YFG7
• Locus tag: AU14_RS02370
• Protein ID: WP_041338597.1
• Coordinates: 523910..524275 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AU14_RS02345 (AU14_02500)	519108..519559	-	452	Protein_527	type II secretion system major pseudopilin GspG	-
AU14_RS02350 (AU14_02505)	519625..520836	-	1212	WP_041338591.1	type II secretion system inner membrane protein GspF	-
AU14_RS02355 (AU14_02510)	520840..522348	-	1509	WP_041338594.1	type II secretion system ATPase GspE	-
AU14_RS20330 (AU14_02515)	522512..522673	+	162	WP_236744313.1	hypothetical protein	-
AU14_RS20335 (AU14_02520)	522670..522837	+	168	WP_236744314.1	type II secretion system protein N	-
AU14_RS02365 (AU14_02525)	523168..523832	+	665	Protein_532	transglutaminase-like cysteine peptidase	-
AU14_RS02370 (AU14_02530)	523910..524275	+	366	WP_041338597.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
AU14_RS02375 (AU14_02535)	524272..525066	+	795	WP_052471940.1	RES family NAD+ phosphorylase	Toxin
AU14_RS02380 (AU14_02540)	525185..526018	-	834	WP_041338599.1	formate/nitrite transporter family protein	-
AU14_RS02385 (AU14_02545)	526192..526818	-	627	WP_236744315.1	hypothetical protein	-
AU14_RS20345	526811..527227	-	417	WP_236744316.1	hypothetical protein	-
AU14_RS02390 (AU14_02550)	527200..528255	-	1056	WP_236744317.1	hypothetical protein	-
AU14_RS20350	528248..530047	-	1800	WP_236744318.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (53-220)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-119)

Sequences

Toxin

Protein

• Length: 265 a.a.
• Molecular weight: 29548.57 Da
• Isoelectric Point: 7.5104

>T46121 WP_052471940.1 NZ_CP007151:524272-525066 [Marinobacter similis]
VSYEERIYRALEPLQGTAYRVVESQEEIATTRLVDNIPEQARLEELLEATKPARAKSTDKLHYLLATPFRYPPLKHGSRF
GRAFEKSLFYGAMTINTALAETAFYRFVFVSHVSAPFPKPLQTLHTVFGARVRSEHGVRLQDSAWQDLHEPLTHPSSYAL
TQSLGTQMRTCGVHCFQFLSARARQAELYRLPYDAGDGMEGINVALFEPSALKDRKPRESSRLIIVTGPESVSMSLTLAD
GSRQVSEFALSSFLIDGRLPDPAA

Nucleotide

• Length: 795 bp

>T46121 NZ_CP007151:524272-525066 [Marinobacter similis]
GTGAGTTATGAAGAGCGCATCTATAGAGCCCTCGAACCGCTGCAGGGAACAGCGTATCGGGTGGTGGAGTCTCAGGAGGA
AATAGCCACCACGCGGCTGGTGGATAACATACCGGAACAAGCCCGCCTGGAAGAGCTACTGGAGGCTACCAAACCGGCTC
GCGCGAAGAGCACCGACAAGCTTCATTACCTGCTGGCCACCCCATTTCGCTACCCACCACTGAAACACGGGTCACGGTTC
GGCCGCGCGTTCGAAAAAAGCCTGTTCTACGGCGCCATGACTATCAACACCGCGCTGGCCGAAACCGCTTTTTACCGTTT
TGTGTTCGTCAGCCATGTGAGTGCGCCATTCCCAAAGCCCCTGCAAACCCTTCACACGGTATTCGGCGCCAGGGTTCGGA
GCGAGCACGGCGTGCGCCTGCAGGATTCCGCCTGGCAGGATCTCCACGAGCCGCTTACCCATCCTTCGAGCTATGCCCTG
ACCCAATCCCTGGGCACCCAGATGCGGACGTGCGGCGTGCACTGCTTTCAGTTCCTGTCCGCCAGAGCGCGACAGGCAGA
ACTGTACCGCCTGCCCTACGATGCCGGAGATGGCATGGAAGGCATCAATGTTGCGTTGTTCGAGCCGAGTGCGCTTAAAG
ACCGGAAACCCCGAGAATCCTCCCGCCTGATAATCGTGACTGGACCGGAATCCGTGTCCATGAGCCTGACGTTGGCGGAT
GGCTCTCGACAGGTTTCGGAGTTTGCTCTGAGCAGCTTTTTAATTGATGGCCGGCTGCCTGATCCTGCGGCGTAA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13387.35 Da
• Isoelectric Point: 9.9116

>AT46121 WP_041338597.1 NZ_CP007151:523910-524275 [Marinobacter similis]
MSTAQLPNEQTQDKALLAKALLNAGKAFGFNQTELADIVGRNRTGLVRDGIDPASKSGELALLFIRLYRSVFALTGGEPA
AMKHWINTENRYFDEVPRQLIKSAEGLVRVNHYLDAMRGKV

Nucleotide

• Length: 366 bp

>AT46121 NZ_CP007151:523910-524275 [Marinobacter similis]
ATGAGTACCGCACAGCTCCCCAACGAGCAAACACAAGACAAAGCACTGCTTGCAAAAGCCCTGCTCAACGCCGGGAAGGC
CTTCGGCTTCAACCAGACCGAACTGGCCGACATTGTGGGCCGGAACCGGACCGGGCTGGTGCGGGACGGCATTGATCCCG
CCAGCAAGTCCGGTGAGCTCGCCCTGCTCTTCATTCGGCTTTACCGCAGCGTATTTGCGCTGACCGGCGGCGAACCTGCG
GCCATGAAGCACTGGATAAACACCGAAAACCGTTACTTTGATGAAGTGCCGCGGCAGCTAATCAAATCGGCGGAAGGGCT
GGTTCGGGTGAATCACTACCTGGATGCCATGCGAGGTAAGGTGTGA

Structures

Toxin

• AlphaFold DB: W5YN87

Antitoxin

• AlphaFold DB: W5YFG7