46116

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 2423207..2423815 Replicon chromosome
Accession NZ_CP007147
Organism Pseudomonas aeruginosa YL84

Toxin (Protein)


Gene name PfiT Uniprot ID A0A444LUU5
Locus tag AI22_RS11070 Protein ID WP_019486378.1
Coordinates 2423468..2423815 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag AI22_RS11065 Protein ID WP_003114155.1
Coordinates 2423207..2423458 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AI22_RS11040 2418227..2418835 + 609 WP_003163344.1 hypothetical protein -
AI22_RS11045 2418845..2419195 + 351 WP_003159569.1 DUF2523 domain-containing protein -
AI22_RS11050 2419197..2420459 + 1263 WP_014603321.1 hypothetical protein -
AI22_RS11055 2420718..2422010 + 1293 WP_003115206.1 hypothetical protein -
AI22_RS11060 2422010..2422993 + 984 WP_025324730.1 tyrosine-type recombinase/integrase -
AI22_RS11065 2423207..2423458 + 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AI22_RS11070 2423468..2423815 + 348 WP_019486378.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AI22_RS11080 2424142..2425044 - 903 WP_025324731.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
AI22_RS11085 2425496..2426233 - 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
AI22_RS11090 2426313..2427356 - 1044 WP_003098363.1 L,D-transpeptidase -
AI22_RS11095 2427492..2428184 - 693 WP_003114159.1 16S rRNA pseudouridine(516) synthase -
AI22_RS11100 2428184..2428456 - 273 WP_073651557.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 2398130..2432919 34789


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12956.72 Da        Isoelectric Point: 4.4212

>T46116 WP_019486378.1 NZ_CP007147:2423468-2423815 [Pseudomonas aeruginosa YL84]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T46116 NZ_CP007147:2423468-2423815 [Pseudomonas aeruginosa YL84]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTCTGCGACAGAAGCAGAGTGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT46116 WP_003114155.1 NZ_CP007147:2423207-2423458 [Pseudomonas aeruginosa YL84]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT46116 NZ_CP007147:2423207-2423458 [Pseudomonas aeruginosa YL84]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGACTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444LUU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References