Detailed information of TA system TA046111

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 5872833..5873858
• Replicon: chromosome
• Accession: NZ_CP007142
• Organism: Gynuella sunshinyii YC6258

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: YC6258_RS24375
• Protein ID: WP_044619191.1
• Coordinates: 5872833..5873399 (-)
• Length: 189 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: A0A0C5VTD8
• Locus tag: YC6258_RS24380
• Protein ID: WP_044619192.1
• Coordinates: 5873406..5873858 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YC6258_RS24360	5868664..5869140	+	477	WP_044619188.1	SsrA-binding protein SmpB	-
YC6258_RS24365	5869722..5870321	-	600	WP_044619189.1	TetR/AcrR family transcriptional regulator	-
YC6258_RS24370	5870486..5872549	+	2064	WP_044619190.1	VIT and VWA domain-containing protein	-
YC6258_RS24375	5872833..5873399	-	567	WP_044619191.1	PIN domain-containing protein	Toxin
YC6258_RS24380	5873406..5873858	-	453	WP_044619192.1	excisionase family DNA-binding protein	Antitoxin
YC6258_RS24385	5874327..5875361	-	1035	WP_211264582.1	DUF91 domain-containing protein	-
YC6258_RS24390	5875873..5876208	+	336	WP_044619193.1	hypothetical protein	-
YC6258_RS24395	5876289..5876621	+	333	WP_044619194.1	hypothetical protein	-
YC6258_RS24400	5876707..5877045	+	339	WP_044619195.1	hypothetical protein	-
YC6258_RS24405	5877235..5878032	+	798	WP_052830551.1	DsbA family protein	-
YC6258_RS24410	5878034..5878303	+	270	WP_044619196.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-112)

Antitoxin

• Helix-turn-helix domain, group 17 (81-126)

Sequences

Toxin

Protein

• Length: 189 a.a.
• Molecular weight: 21647.07 Da
• Isoelectric Point: 5.6188

>T46111 WP_044619191.1 NZ_CP007142:c5873399-5872833 [Gynuella sunshinyii YC6258]
VSKFTVIYDACVLYPAPLRDMLMRLALTDLFKVHWTDQIHEEWINALLRQGKFTREKLERVRDLMDAHARDAKVTGYELL
IDTIQLPDSDDRHVLAAAICCNADAIVTFNLKDFPKEVLKSYSIDVLHPDDFVYYQIDMAPSICCSAIKQQRLALKNPSI
AVDEFLSILQKQQLPQSVSKLREFSDFL

Nucleotide

• Length: 567 bp

>T46111 NZ_CP007142:c5873399-5872833 [Gynuella sunshinyii YC6258]
GTGAGCAAGTTCACTGTCATTTATGATGCATGTGTTCTCTATCCTGCGCCTTTACGAGATATGCTGATGCGATTGGCCCT
TACTGATCTCTTCAAAGTGCATTGGACTGATCAGATTCACGAGGAATGGATCAATGCCTTGCTACGCCAGGGCAAATTTA
CGCGAGAAAAGTTGGAGCGAGTTCGTGATTTAATGGACGCTCATGCGAGAGATGCCAAAGTCACGGGATATGAACTTTTA
ATTGATACCATTCAACTACCAGATTCGGATGATCGTCATGTGCTAGCGGCAGCGATTTGTTGCAATGCTGATGCAATAGT
GACTTTCAATTTGAAGGACTTTCCCAAAGAGGTGCTAAAGTCCTACAGTATTGATGTACTTCATCCCGATGACTTTGTTT
ATTATCAAATTGATATGGCCCCATCGATTTGCTGTTCAGCAATTAAACAGCAGCGATTGGCATTAAAGAACCCTTCAATC
GCCGTAGATGAGTTCCTTTCAATTCTACAAAAACAACAGTTGCCTCAATCTGTATCGAAACTCAGAGAGTTTTCGGATTT
TCTGTAG

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16602.95 Da
• Isoelectric Point: 5.6433

>AT46111 WP_044619192.1 NZ_CP007142:c5873858-5873406 [Gynuella sunshinyii YC6258]
MTTQKIVHLPTPAEVEQAKASGRTLSKYADADRVKLSLRGSNGETDELVLPGQVLQILLDVLSEISKGNAISLIPHHQEI
STQEAANLLNVSRPFLVGLLEKDEIPFRKVGTHRRVLLTDVLAYRDSTKQQRTEALDELAALSQEMDMGY

Nucleotide

• Length: 453 bp

>AT46111 NZ_CP007142:c5873858-5873406 [Gynuella sunshinyii YC6258]
ATGACCACTCAAAAAATAGTCCACCTGCCCACTCCGGCTGAGGTGGAACAGGCTAAGGCTTCAGGCCGCACATTGTCCAA
GTACGCTGATGCAGATAGGGTGAAGTTGTCACTGCGTGGTTCTAATGGTGAGACAGATGAATTGGTGCTGCCTGGCCAAG
TATTGCAAATTCTGTTGGATGTGTTGTCAGAGATTTCAAAAGGCAATGCAATCAGTCTGATCCCACATCATCAGGAAATT
AGTACTCAGGAAGCAGCTAATCTTTTGAATGTAAGTCGCCCTTTTCTGGTTGGTTTGTTGGAAAAGGATGAAATTCCTTT
CCGTAAAGTCGGCACTCACCGTAGGGTGCTTTTAACCGATGTATTGGCTTATCGTGACAGTACAAAGCAACAGAGAACGG
AAGCTTTGGACGAGTTGGCAGCTTTGTCTCAGGAAATGGATATGGGGTACTGA

Structures

Antitoxin

• AlphaFold DB: A0A0C5VTD8