46109

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 36367..36967 Replicon chromosome
Accession NZ_CP007140
Organism Thermococcus guaymasensis DSM 11113

Toxin (Protein)


Gene name vapC Uniprot ID A0A0X1KHP7
Locus tag X802_RS00200 Protein ID WP_062369961.1
Coordinates 36575..36967 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0X1KHQ1
Locus tag X802_RS00195 Protein ID WP_062369960.1
Coordinates 36367..36588 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
X802_RS10825 (X802_00185) 31992..32354 - 363 WP_062369952.1 hypothetical protein -
X802_RS00185 (X802_00190) 32544..33899 - 1356 WP_062369954.1 RsmB/NOP family class I SAM-dependent RNA methyltransferase -
X802_RS00190 (X802_00195) 33982..36309 + 2328 WP_062369957.1 DNA polymerase -
X802_RS00195 (X802_00200) 36367..36588 + 222 WP_062369960.1 hypothetical protein Antitoxin
X802_RS00200 (X802_00205) 36575..36967 + 393 WP_062369961.1 type II toxin-antitoxin system VapC family toxin Toxin
X802_RS10830 (X802_00210) 36960..37136 - 177 WP_169743124.1 hypothetical protein -
X802_RS00205 (X802_00215) 37155..37871 - 717 WP_062369963.1 HAD family hydrolase -
X802_RS00210 (X802_00220) 37919..38173 - 255 WP_062369965.1 hypothetical protein -
X802_RS00215 (X802_00225) 38220..40442 - 2223 WP_062369966.1 DHH family phosphoesterase -
X802_RS00220 (X802_00230) 40658..41197 + 540 WP_245608304.1 DUF2391 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-120)

Antitoxin

Putative antitoxin VapB3-like

(1-73)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14558.87 Da        Isoelectric Point: 5.2646

>T46109 WP_062369961.1 NZ_CP007140:36575-36967 [Thermococcus guaymasensis DSM 11113]
VIVIDASALVKVVLQEPGWEEVPTEPHVATLDYALVEGMNAIWKAVRRGELTTEQGRVKVTVLKTLGSSITLFDARSFFE
RGLEIAFKENITIYDALYIALAEALKAKLLTADEKQYYAAKNYVEARLIR

Download         Length: 393 bp

>T46109 NZ_CP007140:36575-36967 [Thermococcus guaymasensis DSM 11113]
GTGATAGTCATTGATGCCTCGGCCCTTGTGAAGGTCGTTTTGCAGGAACCCGGCTGGGAAGAAGTACCAACGGAGCCACA
CGTGGCGACGCTCGACTATGCACTCGTTGAGGGCATGAACGCAATCTGGAAGGCAGTGCGACGTGGAGAGCTAACAACTG
AGCAGGGCAGGGTCAAGGTAACCGTCCTCAAAACGCTGGGAAGCTCGATAACACTTTTTGACGCCCGGAGTTTCTTCGAG
AGGGGATTGGAGATAGCCTTTAAGGAGAACATCACAATCTACGACGCACTCTACATAGCGCTGGCGGAGGCTCTGAAGGC
TAAACTGCTGACGGCGGACGAGAAGCAGTACTACGCTGCCAAAAATTACGTGGAAGCAAGACTTATCAGGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8654.87 Da        Isoelectric Point: 8.7664

>AT46109 WP_062369960.1 NZ_CP007140:36367-36588 [Thermococcus guaymasensis DSM 11113]
MAIVTVRVPDELKLKMKELDINWSEEIREFIRRRIDEEERKRRIQETLELAKASGSVSRGFAAKSVREDRDSH

Download         Length: 222 bp

>AT46109 NZ_CP007140:36367-36588 [Thermococcus guaymasensis DSM 11113]
ATGGCCATCGTTACTGTCCGCGTTCCCGATGAGTTGAAGCTCAAGATGAAGGAGCTTGACATAAACTGGAGCGAAGAGAT
TAGAGAGTTCATAAGAAGGCGCATAGACGAGGAAGAACGAAAGAGACGAATACAGGAAACATTAGAGCTTGCAAAGGCGA
GTGGAAGCGTGAGCAGGGGTTTTGCAGCGAAGTCCGTGAGGGAGGACCGTGATAGTCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KHP7

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KHQ1

References