Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 5087187..5087803 Replicon chromosome
Accession NZ_CP007139
Organism Fimbriimonas ginsengisoli Gsoil 348

Toxin (Protein)


Gene name vapC Uniprot ID A0A068NZ69
Locus tag OP10G_RS23010 Protein ID WP_025228076.1
Coordinates 5087423..5087803 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A068NX41
Locus tag OP10G_RS23005 Protein ID WP_025228077.1
Coordinates 5087187..5087426 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OP10G_RS22980 5082432..5082845 - 414 WP_144241333.1 hypothetical protein -
OP10G_RS22985 5082865..5083941 - 1077 WP_025228081.1 Gfo/Idh/MocA family oxidoreductase -
OP10G_RS22990 5083957..5084763 - 807 WP_025228080.1 TerC family protein -
OP10G_RS22995 5084851..5085117 + 267 WP_025228079.1 hypothetical protein -
OP10G_RS23000 5085299..5087125 + 1827 WP_025228078.1 hypothetical protein -
OP10G_RS23005 5087187..5087426 + 240 WP_025228077.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OP10G_RS23010 5087423..5087803 + 381 WP_025228076.1 type II toxin-antitoxin system VapC family toxin Toxin
OP10G_RS23015 5088040..5089068 - 1029 WP_025228075.1 serine hydrolase -
OP10G_RS25455 5089065..5090882 - 1818 WP_052547937.1 hypothetical protein -
OP10G_RS23030 5090986..5091234 + 249 WP_025228074.1 hypothetical protein -
OP10G_RS23035 5091322..5092284 - 963 WP_025228073.1 aldo/keto reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(4-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-41)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14304.65 Da        Isoelectric Point: 7.5254

>T46108 WP_025228076.1 NZ_CP007139:5087423-5087803 [Fimbriimonas ginsengisoli Gsoil 348]
VRLLLDTHIAIWVLTDDVRLSQAARELLREPSRNVFYSVVSLWEIGIKHSLGRLDMTPVAVGGGMRDSGFQRLHIADEHL
KRLVTLPFHHRDPFDRMLVAQAEAEPLKLVTSDQRLLVYGSTVLLV

Download         Length: 381 bp

>T46108 NZ_CP007139:5087423-5087803 [Fimbriimonas ginsengisoli Gsoil 348]
GTGAGGCTTCTCCTCGATACGCACATCGCCATCTGGGTTCTTACCGACGACGTCAGGCTGTCCCAAGCCGCCAGAGAACT
ACTTCGCGAACCTAGCCGAAACGTTTTCTACAGCGTGGTGAGCCTGTGGGAGATTGGGATCAAACATAGCCTTGGGCGGC
TGGATATGACACCGGTCGCCGTCGGAGGCGGAATGCGAGACAGTGGATTTCAGCGGCTTCACATCGCCGATGAGCATCTC
AAGCGACTAGTAACCCTTCCGTTCCACCACCGCGACCCTTTCGACCGAATGCTCGTGGCCCAAGCCGAAGCCGAACCCCT
GAAACTCGTCACGAGCGACCAACGGCTGCTTGTTTACGGATCCACCGTACTCTTGGTGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8566.79 Da        Isoelectric Point: 4.4843

>AT46108 WP_025228077.1 NZ_CP007139:5087187-5087426 [Fimbriimonas ginsengisoli Gsoil 348]
MKQVNVHEAKTHLSRLLDEVEAGEDIVIARGGKPAVRLVPFGGDRPGVIGLLKGKMTVSDDFDDPLPEDLLDLFEGKAE

Download         Length: 240 bp

>AT46108 NZ_CP007139:5087187-5087426 [Fimbriimonas ginsengisoli Gsoil 348]
ATGAAGCAGGTGAACGTTCACGAGGCGAAAACCCATCTCTCCCGGCTGCTCGACGAAGTAGAGGCTGGCGAGGATATCGT
CATCGCCCGAGGGGGTAAGCCCGCCGTTCGGCTAGTACCCTTCGGAGGGGACCGGCCCGGGGTTATTGGCCTCCTCAAAG
GCAAGATGACGGTTTCCGACGATTTCGACGACCCGCTTCCCGAGGACCTCCTCGACCTCTTTGAAGGAAAGGCCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068NZ69

Antitoxin

Source ID Structure
AlphaFold DB A0A068NX41

References