Detailed information of TA system TA046024

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 206357..206871
• Replicon: chromosome
• Accession: NZ_CP007065
• Organism: Fusobacterium nucleatum subsp. vincentii 3_1_27

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HMPREF0405_RS09440
• Protein ID: WP_008796320.1
• Coordinates: 206357..206614 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A829KW90
• Locus tag: HMPREF0405_RS09445
• Protein ID: WP_005911998.1
• Coordinates: 206614..206871 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMPREF0405_RS09420	202095..203402	-	1308	WP_008796317.1	electron transport complex subunit RsxC	-
HMPREF0405_RS09425	203476..204051	-	576	WP_005888866.1	aminoacyl-tRNA hydrolase	-
HMPREF0405_RS09430	204194..204931	-	738	WP_008796318.1	tRNA pseudouridine(38-40) synthase TruA	-
HMPREF0405_RS09435	205165..206241	-	1077	WP_008796319.1	DHH family phosphoesterase	-
HMPREF0405_RS09440	206357..206614	-	258	WP_008796320.1	Txe/YoeB family addiction module toxin	Toxin
HMPREF0405_RS09445	206614..206871	-	258	WP_005911998.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HMPREF0405_RS09450	206991..208064	-	1074	WP_008796321.1	glycerophosphodiester phosphodiesterase	-
HMPREF0405_RS09455	208102..209100	-	999	WP_008796322.1	UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	-
HMPREF0405_RS09460	209123..209596	-	474	WP_005892890.1	OmpH family outer membrane protein	-
HMPREF0405_RS09465	209637..211730	-	2094	WP_008796323.1	outer membrane protein assembly factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10159.70 Da
• Isoelectric Point: 8.8765

>T46024 WP_008796320.1 NZ_CP007065:c206614-206357 [Fusobacterium nucleatum subsp. vincentii 3_1_27]
MLLTWTDFAWEQYEELQEKDKRLVKKINILIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKISDTQIIIVAC
ANHYK

Nucleotide

• Length: 258 bp

>T46024 NZ_CP007065:c206614-206357 [Fusobacterium nucleatum subsp. vincentii 3_1_27]
ATGTTATTGACCTGGACTGATTTTGCATGGGAACAATATGAAGAATTACAGGAAAAAGATAAAAGACTTGTAAAAAAGAT
AAATATCCTTATTAAGGATATAAAAAGGAATGGTAATGAAGGAATAGGAAAACCAGAACCTTTACAACATGAGCTAAGTG
GCTATTGGAGTAGAAGAATTGATGATAAAAATAGATTAGTTTATAAGATATCAGATACTCAAATAATAATAGTTGCTTGT
GCAAATCATTATAAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10126.43 Da
• Isoelectric Point: 4.7022

>AT46024 WP_005911998.1 NZ_CP007065:c206871-206614 [Fusobacterium nucleatum subsp. vincentii 3_1_27]
MIATNYSEVRNNLKTYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQKLVESIKEVEKGNVKEHD
LVEVD

Nucleotide

• Length: 258 bp

>AT46024 NZ_CP007065:c206871-206614 [Fusobacterium nucleatum subsp. vincentii 3_1_27]
ATGATAGCAACAAATTATTCAGAGGTTAGAAATAATTTAAAAACTTATTGTGATAAGGCAACAAAGGACTATGAAACTAT
AATTATTACAAGAAAAAATAATGAAAATGTTGTCTTAATGAGTGAAGAAGAATATAACAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAAACTTGTAGAAAGTATAAAAGAAGTTGAAAAGGGTAATGTTAAAGAACATGAT
TTAGTAGAGGTGGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A829KW90