Detailed information of TA system TA046023

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-Axe/YoeB-RelB
• Location: 1756127..1756634
• Replicon: chromosome
• Accession: NZ_CP007064
• Organism: Fusobacterium nucleatum subsp. vincentii 3_1_27

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: HMPREF0405_RS08180
• Protein ID: WP_025374977.1
• Coordinates: 1756127..1756387 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: U7TRN8
• Locus tag: HMPREF0405_RS08185
• Protein ID: WP_005892688.1
• Coordinates: 1756380..1756634 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMPREF0405_RS08150	1751175..1752452	-	1278	WP_008796540.1	D-alanyl-D-alanine carboxypeptidase	-
HMPREF0405_RS08155	1752536..1752922	-	387	WP_008796539.1	Fe-S cluster assembly scaffold protein NifU	-
HMPREF0405_RS08160	1752995..1754191	-	1197	WP_008796538.1	cysteine desulfurase NifS	-
HMPREF0405_RS08165	1754270..1754920	-	651	WP_008796537.1	endonuclease III	-
HMPREF0405_RS08170	1755098..1755586	-	489	WP_008796536.1	GNAT family N-acetyltransferase	-
HMPREF0405_RS08175	1755614..1756117	-	504	WP_025374976.1	GNAT family N-acetyltransferase	-
HMPREF0405_RS08180	1756127..1756387	-	261	WP_025374977.1	Txe/YoeB family addiction module toxin	Toxin
HMPREF0405_RS08185	1756380..1756634	-	255	WP_005892688.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HMPREF0405_RS08190	1756925..1758133	-	1209	WP_025374978.1	tyrosine--tRNA ligase	-
HMPREF0405_RS08195	1758367..1759641	-	1275	WP_008796532.1	branched-chain amino acid transport system II carrier protein	-
HMPREF0405_RS08200	1759789..1760151	-	363	WP_008796531.1	arsenate reductase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10310.83 Da
• Isoelectric Point: 9.3654

>T46023 WP_025374977.1 NZ_CP007064:c1756387-1756127 [Fusobacterium nucleatum subsp. vincentii 3_1_27]
MNNLVWTHKAWQDYLYWQTQDKKTLKKINELVKDIERNGALNGIGKPEVLKNESAYSRRIDEKNRLVYRIIDGFIWIIAC
KGHYEE

Nucleotide

• Length: 261 bp

>T46023 NZ_CP007064:c1756387-1756127 [Fusobacterium nucleatum subsp. vincentii 3_1_27]
ATGAATAATTTAGTATGGACACATAAGGCTTGGCAAGATTACCTATATTGGCAAACTCAGGATAAAAAAACTTTAAAAAA
GATAAATGAATTAGTCAAAGATATTGAAAGAAATGGAGCTTTAAATGGGATAGGTAAGCCAGAAGTATTAAAAAATGAAA
GTGCATATAGTAGAAGAATTGATGAAAAAAATAGACTGGTTTATAGAATTATAGATGGATTTATATGGATAATTGCTTGT
AAAGGTCATTATGAGGAATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9824.17 Da
• Isoelectric Point: 4.4453

>AT46023 WP_005892688.1 NZ_CP007064:c1756634-1756380 [Fusobacterium nucleatum subsp. vincentii 3_1_27]
MLAINYTTLRTNLKSYFDKAVDNDEDIIITRKNERNVVLLSLDKYNEFLKAMRNLEYMTKIREGIAELEAGKGEIHDLIE
VDDE

Nucleotide

• Length: 255 bp

>AT46023 NZ_CP007064:c1756634-1756380 [Fusobacterium nucleatum subsp. vincentii 3_1_27]
ATGTTAGCAATTAATTATACAACTTTGAGAACCAATTTAAAAAGCTATTTTGATAAAGCAGTAGATAATGATGAAGATAT
TATTATAACAAGAAAAAATGAAAGAAATGTTGTTCTATTGAGTCTTGATAAATACAATGAGTTTTTAAAAGCTATGAGAA
ATCTTGAATATATGACAAAAATAAGAGAAGGAATAGCTGAATTAGAGGCAGGAAAAGGAGAAATTCATGATTTAATAGAG
GTTGATGATGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A806UAF3